Brummelhuis, E. (Elke) (2021) HDL cholesterol correlates to recurrent upper respiratory tract infections in young children. thesis, Medicine.
Full text available on request.Abstract
Background Upper respiratory tract infections (URTI) are the most frequent diseases in childhood. Studies in septic patients have shown that high density lipoprotein cholesterol (HDL-C) can play a role in infections. The aim of this study was to determine if the level of HDL-C is also related mild infections, in our study to the total number of days with infections in otherwise healthy children aged 1 to 4 years. Method In this cross-sectional observational study, 118 children aged 1 to 4 years with recurrent URTIs and without a medical explanation for their infections were included. Baseline characteristics were collected by the clinician. Additional data were obtained from 1-month diaries with respiratory symptoms kept by parents of children with URTI. The lipid profile, leukocytes and immunoglobulins were determined. The children were divided in a low HDL-C group (<=1.0 mmol/l) and adequate HDL-C group (>1.0 mmol/l). Results The total number of days with infection in the past month was 14.0 (8.0-22.0) in the low HDL-C group and 8.5 (3.0-16.5) in the adequate HDL-C group (p=0.001). Children with low HDL-C had 1.39 times as many days with infection than children with an adequate HDL-C (p=0.017). Age was a confounder: 0.99 times as many days with infection every month that a child is older (p=0.014). After correction for age, children with low HDL-C had 1.29 times as many days with infection than children with an adequate HDL-C (p=0.067). Conclusion HDL-C inversely correlates with the total number of days with recurrent respiratory infections in children aged 1 to 4 years without a medical explanation for their infections.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Gaag, Dr. E.J. van der |
| Faculty: | Medical Sciences |
| Date Deposited: | 24 Dec 2021 10:48 |
| Last Modified: | 24 Dec 2021 10:48 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2911 |
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