Komdeur, H.M. (Hanna Maria) (2021) Placental lesions in women with chronic kidney disease or kidney transplantation. thesis, Medicine.
Full text available on request.Abstract
Background: Women with chronic kidney disease (CKD) or a kidney transplant (KT) are at increased risk of adverse pregnancy outcomes. Placental lesions such as maternal vascular malperfusion (MVM) may play a role in development of complications during pregnancy in these women. This study examined the association between kidney function and placental lesions in women with CKD and KT. Methods: A retrospective cohort study was conducted, including women with CKD or KT who received obstetric and/or nephrological care at the University Medical Center Groningen (The Netherlands) between 1985 and 2020 and of whom placental reports were available. Data on kidney function, blood pressure values, medication use and pregnancy outcomes of each pregnancy were collected. The primary outcome measure was the presence of a placental lesion, scored following the ‘Amsterdam criteria’. Results: We included 56 pregnancies (CKD: n=36; KT: n=20). Most patients were in CKD stage 1 (n=11), 2 (n=9) and 3a (n=12). We found no differences in kidney function before and during pregnancy between women with and without a placental lesion. MVM was the most common placental lesion in both the CKD and KT group with 36.1% and 25.0%, respectively. Neonates of women with MVM had a lower mean birth weight compared to neonates of women without MVM (1767.9 g ± 625.5 vs 2521.0 g ± 778.0, respectively, p=0.001) and more premature birth (66.7% vs 39.5%, respectively, p=0.049). No significant independent risk factors for developing a placental lesion or pregnancy complications were found in multivariable regression analyses. Conclusion: In this small study, we found no association between kidney function and placental lesions in women with CKD and KT. Future research is needed to evaluate the subject in a larger study with more variety in kidney function.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Jong, dr. M.F.C. de and Schoots, dr. M.H. |
| Faculty: | Medical Sciences |
| Date Deposited: | 24 Dec 2021 08:11 |
| Last Modified: | 24 Dec 2021 08:11 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2901 |
Actions (login required)
 |
View Item |