Erasmus, I. (Iris) (2021) Cardiac time intervals measured by Pulsed Wave Tissue Doppler Imaging as a potential prenatal diagnostic marker in LQTS fetuses. thesis, Medicine.
Full text available on request.Abstract
Background: the long QT syndrome (LQTS) is an inherited cardiac repolarization disorder and one of the main cause of unexplained fetal death. Postnatally the diagnosis can be made relative easily by assessing the QTc on the ECG, but the prenatal diagnosis is more challenging. Prenatal markers to identify fetal LQTS better are needed so appropriate surveillance and therapy can be provided, as required. These prenatal markers could include cardiac time intervals since their mechanical function is linked to the electrical stimulus of the heart. The isovolumetric relaxation time (IRT) represents the last part of the cardiac repolarization, which is prolonged in LQTS patients, which makes it reasonable that the IRT can be used for the prenatal detection of LQTS. Pulsed wave Tissue Doppler Imaging PWTDI) seems a suitable method to perform this. Method: myocardial velocity traces were obtained by PWTDI in six LQTS fetuses and 46 control fetuses. The isovolumetric contraction time (ICT), IRT, the contraction duration (CD) and the cycle length (CL) have been manually measured. The Mann Whitney-U tests was used to compare the time intervals between the study groups. Results: The IRT and CD of the LV and the CD of the LV and RV, were statistically significantly prolonged in LQTS fetuses compared to controls at a gestational age between 30 and 34 weeks (IRT LV, P=0,002; CD LV, P=0,007; CD RV, P=0,050). The CL was, except for the septum at a GA between 26-30 weeks, for all locations statistically significantly prolonged in LQTS fetuses compared to the controls at a GA between 26 and 34 weeks Conclusion: The IRT and CD combined with the fetal heart rate, could be used as a potential prenatal diagnostic markers for LQTS. PWTDI of the LV seems a suitable method to assess this.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Peltenburg, dr. P. J. and Clur, dr. S. A. B. and Martens, dr. F. A. M. C. |
| Faculty: | Medical Sciences |
| Date Deposited: | 23 Dec 2021 14:18 |
| Last Modified: | 23 Dec 2021 14:18 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2897 |
Actions (login required)
 |
View Item |