Balder, J.W. (Jan-Willem) (2014) The use of LDL-c lowering drugs in general population and a future for HDL therapy. thesis, Medicine.
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Abstract
During the scientific internship the student has participated in three projects: 1. Writing a review about the recent developments concerning lowering cardiovascular morbidity and mortality by therapies that increase high-density lipoprotein cholesterol (HDL-c). This review is published in the journal ‘Current opinion in Lipidology’ with the student as first author. 2. Applying the Dutch guidelines concerning the recommendation of cholesterol lowering treatment in primary and secondary prevention to the LifeLines population to investigate the degree of undertreatment. These guidelines use medical history, blood levels, 10-year cardiovascular risk and additional risk factor to decide whether or not an individual would benefit from cholesterol lowering treatment. To estimate the 10-year CVD risk, predication charts based on the Dutch population are used. A syntax based on this prediction chart (written by the student and dr. S. Scholtens) made it possible to use SPSS to estimate the 10-year CVD risk of each participant. After checking for each participant whether or not cholesterol lowering treatment was recommended, this was compared to the actual self-reported cholesterol lowering treatment. The analysis of the student indicates a marked discrepancy between the recommended cholesterol lowering treatment and the actual cholesterol lowering treatment. In primary prevention only 2 out of 10 participants eligible for cholesterol-lowering treatment is taking cholesterol lowering medication and in secondary prevention 7 out of 10. These data are being prepared for publication. 3. Selecting participants from the LifeLines population with extreme lipid phenotypes. Anticipating that there is a strong genetic basis for dyslipidemia in these patients, they will be studied in detail in an ongoing MD/PhD project of the student.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Kuivenhoven, Dr. J.A. and Kamphuisen, Prof. P. W. and UMCG, Department of Pediatrics and Section Molecular Genetics and Department of Internal medici |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:41 |
| Last Modified: | 25 Jun 2020 10:41 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/288 |
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