Ruigrok, L.C. (2020) Darmklachten bij geïsoleerde hypodontie: Zelf gerapporteerde darmklachten bij patiënten met genetisch getypeerde geïsoleerde hypodontie. thesis, Dentistry.
Full text available on request.Abstract
Background: In the majority of the cases isolated hypodontia (IH) is caused by a mutation in the WNT10A gene (1,2). This gene is also involved in regenerative processes in the gastrointestinal mucosa (3,4). A mutation of this gene can therefore affect both processes. Based on theoretical grounds, an association between IH and gastrointestinal complaints can exist, specific under IH patients affected by a WNT10A gene mutation (1-6). The aim of this case-control study is to contribute to the insight towards the genesis of hypodontia. The main question is: ‘What is the association between isolated hypodontia and self-reported gastrointestinal complaints?’. Methods: 28 adults with IH (WNT10A = 17, non-WNT10A = 11) completed the Gastrointestinal Symptom Rating Scale (GSRS), an instrument to obtain self-reported gastrointestinal complaints. Results were statistically analyzed and compared with a matched control group based on age and gender. Results: IH patients scored statistical significantly higher on GSRS total score (p = .018) and on scores related to subscales ‘reflux’ (p = .042), ‘abdominal pain’ (p = .030) and ‘constipation’ (p = .016) compared with controls. Also, the prevalence of symptomatic gastrointestinal complaints was statistical significantly higher under IH patients with respect to total score (p < .05) and scores related to subscales ‘reflux’ (p < .05), ‘abdominal pain’ (p < .05) and ‘constipation’ (p < .05) compared with controls. WNT10A-IH patients scored statistical significantly higher on GSRS total score (p = .041) and on scores related to subscale ‘constipation’ (p = .030) compared with controls. Under WNT10A-IH patients the prevalence symptomatic gastrointestinal complaints was statistical significantly higher with respect to total score (p < .05) and scores related to subscale ‘abdominal pain’ (p < .05). Discussion: IH patients suffered to a worse degree from gastrointestinal complaints compared with individuals without hypodontia. Thereby symptomatic gastrointestinal complaints were more present. This difference was mainly pronounced under IH patients affected by a WNT10A gene mutation. Conclusion: The results support the idea that an association between IH (based on a WNT10A gene mutation) and gastrointestinal complaints exists.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Cune, prof. dr. M.S. and Ross, J.N. |
| Faculty: | Medical Sciences |
| Date Deposited: | 24 Nov 2021 10:32 |
| Last Modified: | 24 Nov 2021 10:32 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2872 |
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