Giusepponi, R. (Raffaele) (2019) Parodontitis en nierfunctie bij transplantatie patiënten. thesis, Dentistry.
Full text available on request.Abstract
Summary: Periodontitis and kidneyfunction in kidney transplant recipients. Introduction: Research shows that periodontitis affects general health as well as several systemic diseases, such as kidney diseases. Specifically, patients with severe periodontitis have a higher chance of developing renal insufficiency as compared to periodontally healthy patients. A progressed kidney disease can lead to kidney failure, resulting in the indication for kidney function replacement therapy, such as kidney transplantation. Moreover, scientific research on the oral health of patients with a kidney transplantation is limited, even though this seems all the more important for these patients to gain adequate kidney functioning. For this reason, the current study will elucidate on this relation, with its main question: what is the relation between periodontal status and kidney functioning in patients with a kidney transplantation up to 10 years after transplantation? Materials and methods: The current research concerns a cross-sectional quantitative patient�dependent study with patients of the Universitair Medisch Centrum Groningen (n = 83) who have had a kidney transplant up to 10 years ago. The used variables are kidney function (mGFR en eGFR) and periodontal status (PISA-score of 6 elements), which have been measured at equal point-in-time. The correlation between the PISA and mGFR/eGFR has been studied using a linear regression analysis. Potential confounders have been investigated using a multiple linear regression analysis. Further, the clinical relevance of the PISA to diagnose a moderate lowered kidney function (GFR<60 ml/min/1,73m2 ) has been investigated using a ROC-analysis. Results: Firstly, PISA appears to be a significant predictor of the mGFR with a predicted decrease in mGFR of 0,076 ml/min/1,73m2 per mm2 (= -,076; t (82)= -2,59; p= ,011). The PISA significantly explains a part of the variance of the mGFR (R 2= ,076; F (1,82) = 6,73; p = ,011). Secondly, the PISA appears to be a significant predictor of the mGFR with a predicted decrease in 0,087 ml/min/1,73m2 per mm2 ( = -,087; t (82)= -3,10; p= ,003). The PISA significantly explains a part of the variance of the eGFR (R 2= ,105; F (1,82) = 9,60; p = ,003). Lastly, the area under the curve of the ROC-analyses for mGFR and eGFR are 0,638 and 0,676 respectively. Discussion: This study shows a negative lineair correlation between the mGFR and eGFR with PISA in patients with a kidney transplantation. The PISA does not seem to be useful as a diagnostic test to determine a moderate decreased kidney function. Nevertheless, maintaining a good oral health can decrease the risk for a decreased kidney function.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Abbas, prof. dr. F. and Borst, prof. dr. M.H. de and Gomes Neto, A.W. |
| Faculty: | Medical Sciences |
| Date Deposited: | 24 Nov 2021 10:25 |
| Last Modified: | 24 Nov 2021 10:25 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2870 |
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