Schaar, J.T. van der (2019) De effectiviteit van digitaal aangemeten MRA’s bij patiënten met licht, matig of ernstig OSAS en de neveneffecten hiervan: een pilotstudie. thesis, Dentistry.
Full text available on request.Abstract
Background The mandibular advancement split (MAS) is a therapeutic device used in treatment of obstructive sleep apnea syndrome (OSAS). The MAS effectively reduces the symptoms of OSAS. Intra-oral scanners allow the possibility to make a digital impression for the composition of the MAS. Objective The goal of this pilot research is to evaluate the effectiveness and short-term side effects of the MAS composed from a digital impression as a form of therapy for treating OSAS. Materials and methods A prospective cohort study examined 30 patients with light, moderate, or severe OSAS. Patients in this study received therapy through a MAS composed from a digital impression. Repeated measurements took place four months after the start of therapy. The primary outcome was the effectiveness of the therapy measured using the Apnea Hypopnea Index (AHI). Secondary outcomes were the snoring percentage, the minimum oxygen saturation, the mean heartrate, the sleepiness measured using the Epworth Sleepiness Scale (ESS), the sleep quality measured using the Pittsburg Sleep Quality Index (PQSI). Further secondary outcomes (temporomandibular dysfunction, complaints by MAS therapy, changes in overjet and overbite) regarded side effects. Other variables that were measured were the therapy compliance and treatment time. Data was gathered with the help of sleep studies, questionnaires and an oral examination. Data collected at the intake has been compared to the data collected four months after the intake. Results have been either statistically analyzed with the Wilcoxon signed-rank test or the McNemar-test. Other data has been described in frequencies. Results A significant decrease was found in both the AHI and ESS. Additionally, a significant increase has been found in the minimum oxygen saturation during sleep, as well as an improvement in quality of sleep. This suggests the MAS composed from a digital impression to be an effective form of therapy for the treatment of OSAS. Patients experienced few short�term side effects caused by the form of therapy. A significant decrease in the overjet and overbite has been measured. The digital workflow for MAS composition has several advantages and disadvantages. Furthermore, the digital workflow includes several labored steps. Conclusion The MAS composed from a digital impression is an effective form of therapy in treating OSAS. There have been reported few short-term side effects of MAS. The digital workflow shows room for improvement, more steps should be digitalized. Comparison of intraoral scans makes an interesting basis for future research on dental side effects of MAS therapy.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Waal, dr. Y.C.M. de and Hoeksema, dr. A.R. |
| Faculty: | Medical Sciences |
| Date Deposited: | 24 Nov 2021 08:14 |
| Last Modified: | 24 Nov 2021 08:14 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2856 |
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