Oude Elberink, M. (Marijn) (2018) Biomarker voor differentiatie in xerostomie patiënten met verschillende etiologie. thesis, Dentistry.
Full text available on request.Abstract
Xerostomy describes the feeling of a dry mouth. Obstacles may occur in primary functions of the oral environment, which can have a major influence on the quality of life. Current diagnosis of xerostomia is often subjective and therefore there is a need for an objective biomarker for xerostomia. The aim of this research is to demonstrate any differences in the lubrication of saliva from xerostomia patients with etiology in primary Sjögren's Syndrome, radiotherapy and medication induced. Xerostomia was simulated by the degree of friction using the tongue-enamel friction model. From this, Relief (V) and Relief Period (VD) were determined as functions of lubrication. The research question was whether V and VD of saliva from xerostomia patients could be a biomarker for differentiating between etiology of xerostomia. . 36 stimulated whole saliva samples from subjects with a mean age of 58.6 years were studied, with some associations found in V, VD and covariates as age and secretion rate. The experience of xerostomia was lower in healthy subjects than in the affected groups. Healthy subjects showed a higher saliva secretion than affected test subjects. At a higher secretion rate, the V seems to drop. Furthermore, a significantly lower V was observed at a higher age. A stronger feeling of xerostomia is significantly related to a lower V. The VD is significantly related to the secretion rate, with a higher secretion rate showing a lower VD. At V and VD a decreasing trend is visible as the age increases. It is striking that the V of xerostomia patients was lower than in healthy test subjects and the VD of healthy test subjects longer. A longer VD in healthy test subjects than in all xerostomia patients could make the difference in the feeling of xerostomia. There are many variables that can influence the results found, such as differences between men and women; overlay between test groups and the oral environment. The hypothesis that there are differences between groups with different aetiology could not be confirmed. Further research with a larger research population and optimization of the tongue-enamel friction model may provide more clarity. With this research a first step was taken by studying differences in etiology.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Sharma, dr. P. K. |
| Faculty: | Medical Sciences |
| Date Deposited: | 23 Nov 2021 13:59 |
| Last Modified: | 23 Nov 2021 13:59 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2845 |
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