Helm, H.C. van der (2018) The effect of Bio-Oss® and Tissucol® on bone regeneration at the mandibular ridge in a Bilateral Sagittal Split Osteotomy: A retrospective volumetric study using Cone Beam Computed Tomography. thesis, Dentistry.
Full text available on request.Abstract
Purpose: A bilateral sagittal split osteotomy (BSSO) can postoperatively create a defect at the mandibular ridge due to the splitting of the mandible. Because the soft tissues can follow the contour of the underlying bone, this can cause an unaesthetic result. A xenograft bone graft could be used to prevent this defect formation by enhancing the bone regeneration. The aim of this study is to investigate if the xenograft Bio-Oss® (BO) in combination with the fibrin glue Tissucol® (TC) enhances bone regeneration at the mandibular border with a BSSO compared to no bone grafting. Materials and methods: This retrospective study included 80 mandibular ridges in 40 patients. In the study group bone augmentation with BO and TC (BOTC) was performed and in the control group no augmentation took place. With Cone Beam Computed Tomography scans (CBCT scans), the mandibular ridges were examined postoperatively (T1) and 12 months later (T2). Using 3-dimensional (3D) software the bone volumes and the heights of the defects were compared for both groups to obtain an indication of the bone regeneration. In addition, the groups were classified into three subgroups according to the horizontal displacement (Group I, 0.0-6.9 mm; Group II, 7.0-8.9 mm; Group III, 9.0-15.0 mm) . Effect sizes were measured for the outcomes of height and volume defect measurements to investigate the effect of the displacement on the bone regeneration. Results: The study group included 20 patients (mean age, 26.1 years; mean horizontal displacement, 8.5 mm) and the control group included 20 patients (mean age, 30.2 years; mean horizontal displacement, 7.6 mm). The study group showed a significant better bone regeneration compared to the control group. The outcomes of subgroup I showed one large effect, subgroup II showed solely large effects and subgroup 3 had negligible effects for all outcomes. Conclusion: With a BSSO, BOTC at the mandibular ridge is successfully used for improving bone regeneration. With large displacement (9.0-15.0 mm) no effect of BOTC was found, but this might be caused by the incorrect use of BOTC. The xenograft BOTC is suggested to increase the aesthetic outcomes of a BSSO, but more prospective research is needed.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Slot, dr. J.W.A. and Schepers, dr. R.H. |
| Faculty: | Medical Sciences |
| Date Deposited: | 23 Nov 2021 13:06 |
| Last Modified: | 23 Nov 2021 13:06 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2833 |
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