Voorthuizen, M. van (Mirthe) (2016) Het effect van een voedingsadvies gedurende drie maanden op het beloop van subklinische hypothyreoïdie bij kinderen : een randomised controlled trail. thesis, Medicine.
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Abstract
Background Subclinical hypothyroidism, defined as a thyroid stimulating hormone (TSH) >4,2 mU/l with normal thyroid hormone (free T4), is a common condition in children. The prevalence is reported between 1,7 and 9,5%. About 40% of the children show normalized TSH within 2 years. There is no current treatment for subclinical hypothyroidism in children. However, several studies in adults showed increased cardiovascular risks. In children, there also seem to be unfavourable effects. We hypothesize that a deficiency of micronutrients (iron, vitamin A, selenium and zinc), which are important for optimal thyroid function, can cause subclinical hypothyroidism in children. Providing these micronutrients, using a dietary advice, could provide faster normalized TSH in children with subclinical hypothyroidism. Objective To evaluate the effect of a dietary advice containing iron, vitamin A, selenium and zinc during three months on subclinical hypothyroidism in children. Study design In this randomised controlled trail, 20 children with subclinical hypothyroidism, aged 1-14 years old, were randomised into a diet group and a control group. The dietary advice consisted of green vegetables 5 times a week, beef 3 times a week and daily full fat milk and dairy butter. TSH, free T4, BMI, lipid profile and fatigue were evaluated at start and after three months. Results Twenty children were included. In the diet group, 3 out of 8 children (37,5%) showed normalized TSH after three months. In the control group, TSH was normalized in 6 out of 6 children (50%)(p=0,670). No other significant changes were observed during the study period. Conclusion This study showed no effect of the dietary advice on normalisation of the subclinical hypothyroidism. However, there was a small number of children included, with only three months follow-up. Therefore, further research should be awaited before conclusions can be drawn on whether a dietary advice consisting of green vegetables, beef, full fat milk and dairy butter can decrease TSH in children with subclinical hypothyroidism.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Gaag, E. van der Kinderarts Ziekenhuisgroep Twente (ZGT) Afd |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:41 |
| Last Modified: | 25 Jun 2020 10:41 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/280 |
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