Volkers, L.S. (2013) Operatie-uitkomsten en overleving bij vrouwen met een BRCA1/2-gerelateerd ovariumcarcinoom in vergelijking met een sporadisch ovariumcarcinoom. thesis, Medicine.
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Abstract
Introduction: Ovarian cancer is relatively rare, but has a poor prognosis. About 10-15% of women with ovarian cancer have an inherited mutation in the BRCA1 or 2 gene. Treatment consists of surgery often followed by chemotherapy. The residual tumor mass after surgery is an important predictor of overall survival (OS). Patients with BRCA1/2 related epithelial ovarian cancer (EOC) respond better to chemotherapy and have a better overall survival than women who have no mutation. Another explanation could be that a better surgical outcome leads to a better OS. Aim of the study: It is unclear whether there are differences in surgical outcomes between women with BRCA1/2 mutations and women with sporadic ovarian cancer. The aim of this study is to see whether there are differences between these two groups and where we can find those differences. Then we look at whether there is a relationship with the OS. Methods: Retrospectively we collected data on patient characteristics and surgical outcomes from 81 patients with BRCA1/2 related ovarian cancer and 94 patients with sporadic ovarian cancer. Data were analyzed using a Pearson’s Chi-square or Fisher’s exact test, Kaplan–Meier and Cox regression. Results: Women with a BRCA1/2 mutation were younger at diagnosis (p < 0.0001), tumors were mostly of a serous type or adenocarcinoma NOS (p = 0.001) and the tumor was more often poorly differentiated (p = 0.003 There was a significant difference in survival (p = 0.044) found between the two groups , even when corrected for residual tumor mass, FIGO stage and tumor grade. After adjusting for age there appeared to be no difference in survival (p = 0.11). There is no difference found in obtaining a complete debulking between the BRCA1/2 and the sporadic group. Between the primary and interval debulking, a number of differences in operating results were found. Conclusion: The OS is significantly better in patients with EOC than in women with sporadic EOC. The residual tumor mass is not an influencing factor. A BRCA mutation has no relation with the achievement of a complete (interval) debulking.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Bock, Prof. Dr. G.H. de and Mourits, Prof. Dr. M.J.E. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:38 |
| Last Modified: | 25 Jun 2020 10:38 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/28 |
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