Veenstra, P. (Pieter (2019) HFNC improves saturation and respiratory rate in patients with an acute exacerbation of COPD. thesis, Medicine.
Full text available on request.Abstract
Background High-flow nasal cannula (HFNC) is already used on a limited scale in COPD-patients. Recent studies demonstrated that HFNC is capable of facilitating secretion removal, reduce the work of breathing and reduce the ventilation of dead space and thereby pCO2. Therefore it might be of advantage in the treatment of acute exacerbations of COPD (AECOPD). This study was conducted to determine the effectiveness of HFNC-treatment in patients with an AECOPD and to assess the different indications used to start HFNC-treatment. Material and methods This retrospective study included patients admitted to the pulmonary ward and treated with HFNC from April 2016 until April 2019. Vital/respiratory parameters and arterial blood gases were obtained in clinical routine, as well as indication for treatment and reason for starting and ending treatment. The primary outcomes were changes in saturation, respiratory rate and pCO2. Results A total of 192 patients were included. HFNC-treatment resulted in a significant reduction of respiratory rate and improvement of saturation. No significant change was seen in pCO2-values. More than half of the patients (55%) ended treatment successfully and stasis of sputum was the indication most reported to start HFNC-treatment. Of the patients admitted with respiratory insufficiency significantly more patients ended treatment non-successfully. Conclusion HFNC is able to reduce respiratory rate and improve saturation in patients with an AECOPD. No positive effect of HFNC on pCO2 was found in this study. HFNC might be less effective for COPD-patients admitted with respiratory insufficiency, and may be of benefit in patients with sputum problems
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Geffen, dr. W.H. van |
| Faculty: | Mathematics ∧ Natural Sciences |
| Date Deposited: | 02 Oct 2020 09:15 |
| Last Modified: | 02 Oct 2020 09:15 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2767 |
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