Schuster, M. (2019) Verhoogde prevalentie van metabool syndroom bij Nederlandse patiënten met een bipolaire stoornis, vergeleken met een geselecteerde controlegroep. thesis, Medicine.
Full text available on request.Abstract
Somatic comorbidity has a significant influence on the reduction in life expectancy, with cardiovascular disease as the most prevalent and influential cause of mortality, in patients with bipolar disorder (BD). Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease and several studies show a higher incidence of MetS in BD. Although, in the Netherlands there are only a few studies with a small sample-size on this subject. Therefore, the aims of this cross-sectional study were to (1) determine the prevalence of MetS in Dutch BD patients in comparison with a selected control group and (2) examine the influence of demographic and clinical characteristics on MetS in BD. Methods: Data analysis of 493 Dutch adult patients (≥ 18 years) with BD receiving psychotropic drugs and 493 selected control patients, was performed by medical data utilization of biobank Lifelines. We determined MetS according to the National Cholesterol Education Program Adult Treatment Panel III-Adapted criteria. Results: BD patients (30,6%) showed a significant higher prevalence of MetS compared to the control group (14,2%). Univariate analysis showed that smoking, body mass index (BMI) and antidepressant drug use were associated with MetS. Multivariate analysis showed that smoking (OR:2.01) was independently associated with MetS in BD. For hypertension, hyperglycemia and lipid disorder pharmacological treatment was provided to respectively 69,5%, 24% and 18,4% of the BD patients in our sample. Conclusion: This study showed a high prevalence of MetS in Dutch BD patients compared to selected controls, with a remarkable undertreatment of some of the components of MetS. Future research is needed to support these findings and should focus on the role of smoking and antidepressant drug use in association with MetS.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Haarman,, Dr. B.C.M. and Chrispijn,, Dr. M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 14 Jul 2020 09:45 |
| Last Modified: | 14 Jul 2020 09:45 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2749 |
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