Prückl, S. (Sarah) (2019) Right Heart Dysfunction Increases Risk for Mortality without Hampering Uptitration Of Medication in New-Onset Heart Failure. thesis, Medicine.
Full text available on request.Abstract
More than 37.7 million people suffer from heart failure worldwide and it is the most rapidly growing cardiovascular condition.(1,2,3,4) Heart failure is seen predominantly as a “left ventricular problem” and can be classified according to left ventricular function.(5,6,7) Treatment of heart failure patients is challenging and research has shown that less than 30% of patients receive the guideline recommended target dose of medication.(8,9) To date, little is known about which factors impair up-titration of medication. It is poorly understood if right heart function plays a role, and what impact it has on de-novo heart failure patients. Therefore this retrospective observational study was set up to investigate which patients have right ventricular dysfunction at diagnosis and what influence right heart function has on medication use, mortality and hospitalization.We found that 37.6% of patients suffered from right heart dysfunction at the time of diagnosis and 19.5% of patients improved over time. Patients with right heart dysfunction commonly had atrial fibrillation, lower left ventricular function, undergone more often thorax surgery and had a lower systolic blood pressure. Right ventricular dysfunction did not hamper the process of up-titration of heart failure medication but did have a negative effect on the risk of mortality in de-novo heart failure patients. Following from this, focusing on the right heart as a potential target for future therapy may be a promising direction for future research in order to improve quality of life and prognosis in patients.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Voors, Prof. Dr. Adriaan and Dickinson, Dr Michael |
| Faculty: | Medical Sciences |
| Keywords: | Cardiology, Heart failure, Mortality, Risk assessment |
| Date Deposited: | 06 Jul 2020 09:58 |
| Last Modified: | 06 Jul 2020 09:58 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2738 |
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