Oberman, M.F. (2014) Langetermijngevolgen van de behandeling van borstkanker: de relatie tussen vermoeidheid en depressie. thesis, Medicine.
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Abstract
Aim: The aim of this research is to assess the relationship between fatigue en depression on the long term in women who have been treated for breast cancer in an unselected population in primary care. The effect of chemo- and/or radiotherapy on this relationship will also be taken into account. Material and Methods: From a population of nearly 36.500 patients, 81 patients with breast cancer and 51 controls without cancer were selected. All patients with breast cancer have been treated after 1970, were younger than 80 years at time of diagnosis, and have had treatment for breast cancer at least five years ago. From the 81 patients with breast cancer 49 have been treated with chemo- and/or radiotherapy, 32 patients were only treated with radiotherapy. The Hospital Anxiety and Depression scale (HADS) and the Multidimensional Fatigue Inventory (MFI-20) were used to assess fatigue and depressive symptoms in patients and controls. Patients who have been treated with chemotherapy and/ or radiotherapy haven been compared within the patient population and with controls by means of the Generalized Linear Model (GLM). Results: After a median follow-up of nine and a half years there was a significant relationship between fatigue and depression (p<.001). A non-significant patient proportion had an increased score of the MFI-20 and the HADS in comparison with the controls. One point increase of the HADS meant for the chemotherapy group a higher score of the MFI-20 (B:2.2; 95% CI:-2.0-2.8) than in comparison with the radiotherapy group (B:0.9; 95% CI:-5.0-6.8). Literature also shows that there is a relationship between fatigue and depression, it is not clear if type of therapy has an influence on this relationship. Literature displays that a significant part of women who have had breast cancer experience complaints of fatigue and depression for years after treatment. Women treated with chemotherapy seem to be more fatigued in comparison with women who have not been treated with chemotherapy for breast cancer. Conclusion: There is a relationship between fatigue and depression in breast cancer survivors on the long term. This is in accordance with literature research. Chemo- and radiotherapy do not have a significant influence on this relationship. This study shows that a non-significant greater proportion of patients have an increased score at the MFI-20 and HADS in comparison with the controls. Literature shows that a small significant part of women who have had breast cancer keeps suffering from fatigue and depression on the long term. This study further shows that in comparison with patients who are only treated with radiotherapy, patients treated with chemotherapy have a higher score at the MFI-20 when the HADS increases with one point. This relationship however doesn’t differ significantly. Literature shows that women treated with chemotherapy seem to be more fatigued in comparison with women who have not been treated with chemotherapy for breast cancer.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Berendsen, Dr. A.J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:07 |
| Last Modified: | 25 Jun 2020 11:07 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2724 |
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