Brunekreef, T. (Tammo) (2017) Development of secondary Sjögren’s syndrome and sicca symptoms in patients with rheumatoid arthritis. thesis, Medicine.
Full text available on request.Abstract
Development of secondary Sjögren’s syndrome and sicca symptoms in patients with rheumatoid arthritis Background: Patients with rheumatoid arthritis (RA) can develop sicca symptoms, as well as secondary Sjögren’s syndrome (sSS). The etiology, course and treatment of this disease are largely unknown. Objectives: To describe the changes in prevalence and the course of sicca symptoms and sSS in patients with RA, as well as the factors that are of influence on developing these symptoms. Methods: 96 patients out of a longitudinal cohort formed in 2007 were asked to participate in the screening for sicca symptoms and sSS. Patients underwent clinical evaluation of disease activity of RA by DAS-28 score and evaluation of the function of the lacrimal and salivary glands by Schirmer’s test and sialometry of the submandibular/sublingual and parotid glands. Patients were also asked to fill in multiple questionnaires. Clinical parameters were compared between RA-patients with sSS, RA-patients with at least one sicca symptom and RA-patients without sicca symptoms. These groups were also compared longitudinally with the groups from the first screening. Results: 31 (32.3%) out of 96 patients of the 2007 cohort were screened again in 2017. The characteristics of the patients participating in screening 2017 did not differ significantly from the patients who did not participate in screening 2017. The prevalence of sSS and sicca symptoms was 12.9% and 32.3% respectively. Patients with sicca symptoms and sSS experienced more fatigue and had a worse assessment of their health compared to patients without these symptoms. Patients in all groups had declined functional tests compared to 2007. Conclusion: The prevalence of sSS and sicca symptoms was 12.9% and 32.3%, comparable to the percentages of screening 2017. Interestingly, a relatively large group of patients (35.5%) developed new symptoms or did not have them anymore, 10 years after first screening. Higher disease activity of RA, the presence of extra-articular manifestations and worse score on HAQ seemed to be associated with the presence of sSS and sicca symptoms.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Under supervision of and Bootsma, Prof. H. and and and Moerman, R.V. and Department of Rheumatology and Clinical Immunology, Universi |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:07 |
| Last Modified: | 25 Jun 2020 11:07 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2720 |
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