Visser, F. (Fenny) (2011) Biosfonaten en het ontstaan van osteonecrose : een Systematic Review. thesis, Dentistry.
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Abstract
Background: Bisphosphonate-related osteonecrosis is a complication in long-term intravenous bisphosphonate use. Objective: In this article the risk of developing osteonecrosis is reviewed, along with de most important risk factors in de development of osteonecrosis and the developing time of osteonecrosis. Methods: Relative articles are identified by searching the databases 'Scopus' and 'Pubmed'. Results/conclusion: Bisphosphonate related osteonecrosis is a condition that is thought to be related to the long-term administration of primarily intravenous bisphosphonates in cancer patients. Various risk-factors are related to the development of osteonecrosis of the jaw, for example the type of bisphosphonates that are administered, undergoing an extraction or oral surgery, and the presence of other oral manifestations. Further investigation is needed to decide if other factors have influence in the development of osteonecrosis. The course of treatment is thought to be the most important factor in the development of osteonecrosis. In the administration of zoledronate the development of osteonecrosis can be expected in a matter of months, whereas in the administration of pamidronate this will be a matter of years. Prior to the onset of the bisphosphonate treatment, the patient will be referred to a specialist for a full oral examination. The focus will be on detecting any possible future inflammation site, and remove it. This way, the need for (invasive) dental treatment during bisphosphonate therapy will be restricted to a minimum.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Begeleider and Witjes, Dr. M.J.H. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:07 |
| Last Modified: | 25 Jun 2020 11:07 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2700 |
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