Sinusoidal high intensity exercise training in COPD patients with ventilatory limitation.

Oenema, B. (Berend) (2014) Sinusoidal high intensity exercise training in COPD patients with ventilatory limitation. thesis, Medicine.

Text OenemaB.pdf Restricted to Registered users only Download (757kB)

Abstract

Pulmonary rehabilitation (PR) is an effective treatment in Chronic Obstructive Pulmonary Disease (COPD) patients. Although high intensity training can improve exercise capacity in COPD patients more than lower intensity training, training intensity is often restricted due to ventilatory limitation. Recently, it has been shown that COPD patients are able to exercise on a high-intensity rapid sinusoidal work rate (SW) reaching 120% of incremental peak work rate (PWR) on a cardiopulmonary exercise test (CPET) without reaching ventilatory limitation. We therefore investigated whether this training protocol resulted in a larger training effect at work rate 6 minutes (WR6) than the traditional constant work rate (CWR) training. In this study, 7 CWR (age, 62.7 ± 8.7 years; forced expiratory volume in the first second (FEV1), 44.0 ± 19% of predicted) and 6 SW subjects (age, 70.2 ± 8.1 years; FEV1, 50.6 ± 21% of predicted) underwent pulmonary function test and CPET. Subjects reached at least 40 watts during CPET and were all ventilatory limited. 4 CWR tests were performed to obtain the critical power (CP), the power defined as the maximal work rate that can be maintained for at least 20 minutes. Quadriceps muscle strength was measured by 1RM. Subsequently, subjects were randomized between SW or CWR training and underwent a 4 week exercise training program. After the last training, initial exercise tests and 1RM were repeated. Exercise training in both groups resulted in a greater increase of exercise endurance at WR6. PWR increased by 4 watts to 86 watts (CWR) and 3.7 W to 81 W (SW). CP increased from 51.4 to 58.2 W (p<0.05) CWR and from 44.1 to 48.9 W (p=0.116) SW. in both groups, 1RM increased significantly from 275 to 305 lbs (CWR) and from 306 to 341 lbs (SW). No significant differences were found between the groups. These results emphasize the benefits of high intensity exercise training on exercise capacity. No benefits were seen in favor of SW training or CWR, possibly explained by the power of the study (preliminary data).

Item Type:	Thesis (Thesis)
Supervisor name:	Vaart, dr. H van der
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 11:07
Last Modified:	25 Jun 2020 11:07
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/2696

Actions (login required)

View Item