Chen, C.S.A. (2013) De relatie tussen ovariële chirurgie en het risico op een trisomie zwangerschap. thesis, Medicine.
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Abstract
Background: This study is part of a research line which focuses on the relation between follicle pool size and the risk of a trisomic pregnancy. Not much is known about the relation between ovarian surgery, an iatrogenic cause of diminished ovarian reserve, and the occurrence of a trisomic pregnancy. A previous Dutch study in 2010 of subfertile women who underwent IVF treatment a statistically significant association was found between parameters which lead to a diminished ovarian reserve and the occurrence of a trisomic pregnancy. One of these parameters is ovarian surgery. This study indicated that women with previous ovarian surgery more often had a trisomic pregnancy than women of the same age without trisomic pregnancy(1). In this study we will try to confirm the relation between previous ovarian surgery and trisomic pregnancy, by repeating the study in a larger non-Dutch general population. Methods: A retrospective case-control study was designed to assess the relation between previous ovarian surgery and trisomic pregnancy. Trisomic cases and controls were selected from the Danish general population, including fertile and IVF-treated women from 1995 to 2010. The women with trisomic pregnancies were selected regardless of the outcome of the pregnancy (termination, miscarriage or a live born child). Women with a live born child without a trisomy served as controls. For each case we selected four controls matched on female age at the estimated date of conception. The proportion of women with a history of ovarian surgery will be compared between cases and controls. Results: 8714 women were included in the study; 1744 trisomic cases and 6969 controls. 48 (2.8%) women in the trisomic group and 180 (2.6%) in the control group have had ovarian surgery. Logistic regression analysis showed no significant association between previous ovarian surgery and trisomic pregnancy in a general population [odds ratio (OR) 1.06; 95 % confidence interval (CI): 0.77-1.47; P=0.69]. Conclusion: The current study does not confirm the associaton between ovarian surgery en trisomic pregnancy that was previously found by Haadsma et al.(1) in an IVF population.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Begeleider: and Groen, Dr. H. arts-epidemioloog and Lokatie onderzoek: Universitair Medisch Centrum Groningen and Afdeling: Epidemiologie |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:07 |
| Last Modified: | 25 Jun 2020 11:07 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2672 |
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