Kuiper, M. (2016) The influence of dynamic light conditions on visual functioning in healthy subjects. thesis, Medicine.
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Abstract
Glaucoma is a chronic progressive optic neuropathy, which could lead to irreversible blindness if left untreated. Many glaucoma patients have difficulties with seeing in changing light conditions. The primary aim of this study is to determine reference values of (1) light and dark adaptation time and (2) contrast gain control. In this cross-sectional study 46 ophthalmic healthy subjects participated, between the age of 40 and 70 years. All performed a light and dark adaptation test and a perimetry test in dynamic light conditions. After an increase or decrease in luminance with 5 log units, light and dark adaptation were tested respectively with central contrast sensitivity tests using the staircase method. A perimetry test was performed on a computer screen with the background luminance modulated in time. Contrast gain control was defined as the difference of the, with perimetry tested, contrast sensitivity in static and dynamic light conditions. The reference values of light and dark adaptation time and contrast gain control were determined. Light adaptation depends on time (p=2.72*10-12) and this effect depends on age (p=0.0002). The dark adaptation also depends on time (p<2*10-16). Contrast gain control depends on eccentricity (p=3.51*10-8) and polarity of the stimulus (p=0.0003). A further study will assess light and dark adaptation time and contrast gain control in glaucoma patients. Data of both studies will be compared to objectify the complaints of glaucoma patients in dynamic light conditions.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisors: and Bierings R.A.J.M. MSc & and Jansonius, prof. dr. N.M. and Ophthalmology department UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:07 |
| Last Modified: | 25 Jun 2020 11:07 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2666 |
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