Neuman, L.M. (2019) Validatie van de m-PTBS in een Nederlands ziekenhuis: een accuraat voorspellingsmodel voor de diagnose reuscel arteritis : Een retrospectief dossieronderzoek. thesis, Medicine.
Full text available on request.Abstract
Background: The complications of giant cell arteritis (GCA), such as blindness and ischemic stroke, can be prevented by rapid initiation of treatment. This requires early and accurate diagnosis. Recently, Laskou et al. (2019) developed the pre-test probability score (PTBS) that allows physicians to assess the likelihood of GCA at an early stage. The PTBS can be used with or without ultrasonography. Objective: External validation of the PTBS in a peripheral, Dutch hospital. Methods: A retrospective review of records was conducted of patients suspected of GCA in Ziekenhuisgroep Twente from 01-01-2017 to 01-06-2018. As the item ˊextra-cranial artery abnormalityˊ in the PTBS was unknown in all patients, a modified version of the PTBS was validated: the m-PTBS. The m-PTBS was compared with the final diagnosis of GCA, determined by the rheumatologist after six months. The m-PTBS was tested for discrimination and calibration. Results: 103 patients were included, of which 68 had complete records. Of these 68 patients, 25 had GCA. The m-PTBS had an ˊarea under the receiver operating characteristic-curveˊ (AUC) of 0.898, a sensitivity of 92.0% and a specificity of 76.7% at cut-off point 10.5. After multiple imputation the AUC was 0,862 - 0,880, sensitivity was 82,4% - 85,3% and specificity was 73,9% - 78,3%. The calibration plot showed a deviation from the ideal line at low predicted risk of GCA, however the Hosmer-Lemeshow test was non-significant. Conclusion: The m-PTBS showed good discrimination and reasonable calibration in a peripheral, Dutch hospital
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Alves, dr. C. reumatoloog and Locatie: Ziekenhuisgroep Twente (ZGT) and Afdeling: Reumatologie |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:07 |
| Last Modified: | 25 Jun 2020 11:07 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2658 |
Actions (login required)
 |
View Item |