Vorst, N.E. van der (2018) Inaccuracy of the Colon Leakage Score in left and right-sided colorectal surgery. thesis, Medicine.
Full text available on request.Abstract
Background: Anastomotic leakage (AL) is a severe and frequent complication after colorectal surgery. The Colon leakage score (CLS) is developed to assess the risk of developing AL based on pre-and intra-operative factors, for patients with left-sided colonic and rectal anastomosis. The aim of this study is to verify the utility of this score and explore if the CLS is also applicable for right sided colonic anastomosis. Patients and methods: Patients were included from an existing prospective cohort. Hundredseventy- eight patients were included in the group with rectal and left-sided anastomosis and 153 patients were included in the right-sided group. In each group the CLS between patients with and without AL were compared. The predictive value and area under the receiver operating curve (AUC) were calculated. Additional logistic regression analysis was performed. Results: There were only significant differences in mean CLS for patients with left-sided (Pvalue = 0.015) and right-sided anastomosis (P-value = 0.041). However, the AUCs and odds ratios in both cases were low (left-sided, AUC = 0.653 (CI 0.477 – 0.828); odds ratio = 1.295 (CI 1.040 – 1.614; p=0,021)) (right-sided, AUC = 0.672 (CI 0.518 – 0.827); odds ratio = 1. 195 (CI 1.003 – 1.423)). Conclusions: The CLS did not hold up as a good predictor for the occurrence of AL for patients who either received a rectal, left-sided or right-sided colonic anastomosis in the present study. To create a more comprehensive and accurate score, large cohort multiple regression analysis should be considered in the future.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Havenga, Dr. K. |
| Supervisor name: | Second Supervisor: and Boerma, Dr. D. and Department of Surgery St. Antonius Hospital and Nieuwegein |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:07 |
| Last Modified: | 25 Jun 2020 11:07 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2650 |
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