Metzemaekers, L. (2012) Vergelijking van twee ziekte-specifieke vragenlijsten bij patiënten met zowel COPD als hartfalen :Op basis van psychometrische eigenschappen en voorkeur van patiënten. thesis, Medicine.
Full text available on request.Abstract
Background: Prevalence of patients with both Chronic Obstructive Pulmonary Disease (COPD) and heart failure has increased last decennium. These two diseases share similar symptoms, risk factors and poor Health Related Quality of Life (HRQL). Currently, health status in patients with both COPD and heart failure is assessed with two or more disease specific questionnaires. To investigate whether this can be reduced, we compared psychometric performance and patient preference of the Clinical COPD Questionnaire (CCQ) and the Minnesota Living with Heart Failure Questionnaire (MLHF-Q). Methods: In a pilostudy the internal consistency, concurrent validity, convergent validity, discriminant validity, reproducibility, responsiveness and patient preference were determined. The Short Form-36 (SF-36) was used as external criterion. CCQ, MLHF-Q and SF-36 were completed at the start of the study. After 2 and 12 weeks the questionnaires were repeated, together with a Global Rating of Change instrument. Between 2 and 12 weeks patient preference was assessed using a self-made questionnaire. Results: 38 patients were included. Internal consistency was adequate for the CCQ (Cronbach’s α 0.72 to 0.86) and MLHF-Q (Cronbach’s α 0.84 to 0.89), except for CCQ domain symptoms (Cronbach’s α 0.70). Concurrent validity showed significant correlations between corresponding domains of the CCQ and the SF-36 (rs -0.33 to -0.76), except corresponding SF-36 domain role-emotional (rs -0.19, p=0.25). Corresponding domains of the MLHF-Q and SF-36 were also significantly correlated (rs -0.33 to 0.67), except corresponding SF-36 domain pain (rs -0.28, p=0.09). Convergent validity showed strong significant correlations between MLHF-Q and CCQ (rs 0.71 to 0.83), but weak correlations between CCQ domains symptoms and functional and MLHF-Q (rs 0.37 to 0.64). Reliability of CCQ and MLHF-Q in stable patients was high (intraclass correlations coefficients 0.89 to 0.97 and 0.87to 0.93). Bland-Altman plots showed small mean differences for CCQ total (-0.03 (±0.34)) and MLHF-Q total (0.00 (±10.51)), indicating good agreement. Discriminant validity and responsiveness were inconsistent in both questionnaires. There were floor effects for domains CCQ mental and MLHF-Q emotional, but no ceiling effects for both questionnaires. Patients appeared to prefer the CCQ. Conclusion: CCQ and MLHF-Q were valid and reliable instruments to measure HRQL in patients with both COPD and heart failure. Based on the results found in this study there is a slight preference for the CCQ.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultaire begeleider: and Berg J.W.K. van den (longarts) and Medebegeleiders: and Uil drs S. M. (gezondheidswetenschapper) and Locatie: Isala Klinieken Zwolle, locatie Weezenlanden. Afdel |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:06 |
| Last Modified: | 25 Jun 2020 11:06 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2560 |
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