Meer, A.S. van der (2017) Relatie tussen spierkracht en prednisolon-gebruik bij patiënten met anti-neutrofiel cytoplasma antistoffen geassocieerde vasculitis. thesis, Medicine.
Full text available on request.Abstract
Introduction: Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis patients are treated with high doses of prednisolone. A common side effect of prednisolone is skeletal muscle atrophy. This might affect muscle strength, which might result in reduced mobility and quality of life. However, the exact relationship between prednisolone use and muscle strength is not clear. The primary aim of this study was to investigate the relationship between muscle strength and current and cumulative prednisolone dose. Also, we aimed to investigate the relationship between muscle strength, mobility and quality of life. Methods: The population consisted of 46 patients, diagnosed with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) and treated with prednisolone as part of their induction or maintenance treatment. A correlation analysis was used to investigate the association between muscle strength and current and cumulative prednisolone dose, and between muscle strength and mobility en quality of life. Results: Compared to a matched control group from previous literature, ANCA-associated vasculitis patients had a significantly lower muscle strength (266 ± 79 versus 296 ± 49 N; P<0.001). Muscle strength was not significant correlated to current (Rho = -0.11; P = 0.47) or cumulative (Rho = -0.06; P = 0.69) prednisolone dose. It was also not significantly related to mobility (Rho = 0.08; P = 0.63). Muscle strength was positively correlated to the physical domains of quality of life (Rho = 0.31; P = 0.04). Conclusion: Muscle strength was not related to current and cumulative prednisolone dose. It was also not related to mobility. A higher muscle strength was associated with a higher quality of life.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Stegeman, Prof. Dr. C.A. and Tweede begeleider: and Rutgers dr. A and Locatie: . and Medisch Centrum Groningen (UMCG), afdeling interne geneeskun |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:05 |
| Last Modified: | 25 Jun 2020 11:05 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2504 |
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