San Giorgi, M.R.M. (2012) HPV 6 And HPV 11 induce a different clinical course in recurrent respiratory papillomatosis. thesis, Medicine.
Full text available on request.Abstract
Introduction: Contradictory results on the aggressiveness of recurrent respiratory papillomatosis (RRP) either caused by HPV 11 or HPV 6 have been reported. Some studies attribute a worse clinical course to HPV 11. Most used inconclusive virus typing methods. This investigation aims to describe differences in clinical course of RRP caused by HPV 6 or HPV 11 proved by HPV type specific polymerase chain reaction (PCR). Material and methods: A retrospective cohort study of 54 patients diagnosed with RRP between 1974 and 2012 was performed. All patient charts, operation reports, video and photo documentation were retrospectively analyzed. Surgeries were scored on the Derkay score, the Dikkers score and complications. Results: The median of surgeries per patient was 5 for both groups with a median follow-up of 9 years. There was significant difference (p=0.037) in total surgical frequency between the HPV 6 and HPV 11 group. The HPV 11 group showed significantly more extralaryngeal involvement, distal involvement and a higher mean Derkay score. Conclusion: The surgical frequency in patients with RRP is highest in the first years after diagnosis. HPV 11 induces a prolonged higher frequency of surgeries, more extralaryngeal and distal involvement. HPV 11 attributes to a more aggressive clinical course.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Dikkers, dr. F.G. and Tjon Pian Gi, drs R.E.A. and Otolaryngology and Head & Neck Surgery UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:05 |
| Last Modified: | 25 Jun 2020 11:05 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2467 |
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