Bouw J.S. (2013) De lokale controle van brachytherapie versus chirurgie bij plaveiselcelcarcinomen van de onderlip. thesis, Dentistry.
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Abstract
Background and purpose The term lip carcinoma is used to describe squamous cell carcinoma of the vermillion border of the lips. This type of tumor is mostly localized on the lower lip. The disease is most frequently seen with older white males whom have passed the age of 40. Both brachytherapy and surgery are recommended as curative treatment. Brachytherapy is a radiation technique that provides radiation from within the tissue. Radioactive sources are implanted inside the tumor tissue. There are several options to obtain a radical removal of the tumor through surgery. Basically these options consist of three surgical techniques: lipshave or vermillionectomy, wedge excision, and bloc resection. The purpose of this studies is to compare brachytherapy and surgery as primary, curative treatment of squamous cell carcinomas (Tl NO, T2NO) of the vermillion border of the lower lip. Local control rates and side effects of both treatments are evaluated into detail. Materials and methods From January 2005 to December 2011,49 patients underwent surgery or brachytherapy as a primary, curative treatment ofT1 and T2 squamous cell carcinoma of the vermillion border of the lower lip. Data about tumor staging, tumor size, treatment, side effects and oncologic outcomes were obtained from digital patient files and were recorded carefully in tables. Results A local control outcome of 82.6% was obtained in the brachytherapy group after a median follow-up period of 32.0 months (SD: 16.3). In the surgery group, a local control outcome of 100% was obtained after a median follow-up period of 47.7 months (SD:21.3). All patients suffered from mucositis after brachytherapy. As regards most of the patients, namely 39.1 %, the mucositis was cured within merely a month. Concerning the surgery groups, 55.2% of the patients reported no complaints at all. Conclusion Brachytherapy as a treatment for T1-2 squamous cell carcinomas of the vermillion border of the lower lip, is the treatment of choice if surgery can lead to serious functional or esthetic damage. Local recurrence after brachytherapy can be successfully treated with salvage surgery.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Roodenburg, Prof. Dr. J.L.N kaakchirurg-oncoloog and Bijl, Dr. H.P radiotherapeut-oncoloog |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:05 |
| Last Modified: | 25 Jun 2020 11:05 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2457 |
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