Alsabaan, N. (Najod) (2018) The effect of smoking on cardiac structure and function. thesis, Medicine.
Full text available on request.Abstract
Background: cardiovascular disease (CVD) is the main cause of mortality worldwide. Smoking is an important risk factor for CVD. The mechanism linking smoking with CVD is not yet clear. Most of the evidence for the effects of smoking in relation to cardiac structure and function is based on echocardiography. Magnetic resonance imaging (MRI) has high spatial and temporal resolution and is more accurate in assessing cardiac structure and function. Therefore, the aim of this study was to assess the effects of smoking on cardiac structure and function as assessed by MRI. Methods: this case-control study included participants from the UK biobank study free from major CVD. Smokers and non-smokers were matched on age, sex and body surface area. MRI imaging analysis was performed using CircleCvi42 post-processing software. Independent t-test, Mann-Whitney U test and chisquared test were performed to compare the data between smokers and non-smokers. Bonferroni correction was conducted to correct for type one errors. Results: we matched 103 smokers with non-smokers. The mean age was 58 (7.5) years. Smokers consumed more units of alcohol (P= 0.024) and had lower incomes (P= 0.015) as compared to non-smokers. Global longitudinal strain (GLS), global radial strain (GRS) and ejection fraction (EF) were lower in smokers as compared to non-smokers (P-value= 0.002, 0.01and 0.012, respectively). After Bonferroni correction, GLS remained the only significant variable with lower values in smokers as compared to non-smokers. Conclusion: Our results add to the knowledge on the effects of the established cardiac risk factor smoking on cardiac structure and function by showing a significantly lower GLS in smokers as compared to non-smokers. These results seem to indicate that smoking causes subclinical alterations in myocardial function, which are possibly due to changes in myocardial structure.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Harst, Prof. dr. P. van der Interventional Cardiologist and Cardiac Catheterization Laboratory, p.van.der.harst@umcg.nl and 2nd supervisor: and Dijk, Drs. R. van and 3rd supervisor: and Hendriks, Drs. T. and Research institution: University Medical Centre Groningen (U and Groningen, Groningen and Research department: Department of Cardiology |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:04 |
| Last Modified: | 25 Jun 2020 11:04 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2440 |
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