Venema, C.S. (2019) Influence of cardiopulmonary bypass on sublingual microcirculation during cardiac surgery: an observational study. thesis, Medicine.
Full text available on request.Abstract
Background. The use of cardiopulmonary bypass (CPB) during cardiac surgery is associated with physiologic derangements, including a systemic inflammatory response. CPB may thereby disturb the integrity of the microcirculation, possibly increasing the risk of postoperative complications. The primary aim of this study was to determine the influence of CPB on the microcirculation. The secondary aim was to determine whether changes in microvascular variables are associated with the occurrence of postoperative complications. Methods. Sublingual microvascular videos were made using incident dark field imaging in twelve patients undergoing cardiac surgery with CPB. Microvascular variables were compared at three time points: before, during and after CPB. We recorded complications in the first 30 days after surgery according to the definitions for perioperative outcomes from the European Society of Anaesthesiology and European Society of Intensive Care Medicine. Results. During CPB, microvascular flow index (MFI) decreased from 2.7 to 2.3 (p < 0.01), whereas other microvascular variables remained stable. Microvascular changes did not differ in patients with and without complications. Conclusion. In this prospective observational study, we found that MFI decreases during CPB. We did not find an association between microvascular changes and postoperative complications
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and Scheeren, T.W.L. MD PhD and Second supervisor: and Kaufmann, T. MD and Department of Anesthesiology and University Medical Center Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:04 |
| Last Modified: | 25 Jun 2020 11:04 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2403 |
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