Bucher, T. (Tamara) (2013) Kenmerken van de tonische reactie bij de kniepeesreflex bij zuigelingen met risico op cerebrale parese. thesis, Medicine.
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Abstract
Introduction: Cerebral palsy (CP) is a relatively frequently occurring developmental problem. It is caused by brain lesions that occur during early development. Notwithstanding its relatively high prevalence, early prediction of CP remains difficult. Therefore, part of the research at the Institutue of Developmental Neurology at the University of Groningen (UMCG) aims finding parameters which can predict at early development which infants are at risk to develop CP. In the Learn 2 Move 0-2 years (L2M 0-2) study, in which infants with a high risk for CP are examined neurologically, some infants showed a tonic response at the knee jerk instead of the normal short phasic response. This phenomenon has not been described; it could be an early predictor of CP later in life. Methods: This explorative patient study included 15 infants from the L2M 0-2 study with a high risk to develop CP. Knee jerk of the infants had been examined at four moments until the age of 21 months. The existing knee jerk data consisted of video and EMG-recordings of leg-, arm-, shoulder-, nek- and trunk muscles during multiple knee jerks per asssessment. The videos were analysed with a standardized scoring form and the EMG data with the PedEMG program. Statistics mainly consisted of descriptive statistics, occasionally non-parametric tests where used to explore possible associations. Results: The infants at high risk for CP showed occassionally to frequently tonical activity in response to the knee jerk. The frequency and duration of the tonic responses varied substantially and did not change over time. Tonic activity in response to the knee jerk was not asssociated with the development of CP at 21 months. However, a negative association was observed between tonical responses and the occurrence of reciprocal excitation (contraction of the agonist muscle) and knee jerk reflex irradiation. Conclusion: The results of this explorative study showed that infants at high risk for CP relatively often show a tonic response at the knee jerk. The occurrence of the tonic responses was not associated with the development of CP at the age of 21 months. Further research with healthy infants is needed to see if tonic responses are also seen in this group, to elucidate whether tonic responses are part of typical myotatic reflex development.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Hadders-Algra, Prof. Dr. M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:04 |
| Last Modified: | 25 Jun 2020 11:04 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2385 |
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