Ali, R. (Ramon) (2012) HET EFFECT VAN SEVOFLURAAN IN VERGELIJKING MET PROPOFOL OP DE MATE VAN RENALE ISCHEMIE-REPERFUSIE SCHADE BIJ NIERTRANSPLANTATIES MET LEVENDE DONOREN. thesis, Medicine.
Full text available on request.Abstract
Background: Volatile anesthetics protect against cardiac ischemia-reperfusion injury (IR injury) eg by opening mitochondrial K ATP channels. Studies on the protective effects of volatile anesthetics on the kidney are limited to in vitro and in vivo animal studies. These studies have shown that in the presence of sevoflurane suppression of pro inflammatory effects seen by the up-regulation of cytokine mRNA and ICAM1 to modulate. This study investigates the effect of sevoflurane on IR damage in living donor kidney transplants. Method: Within the already ongoing research VAPOR, 2 research groups were used. The SEVO group in which both the donor and recipient sevoflurane were administered, and the SERE group in which the donor and recipient sevoflurane, propofol was administered. Urine samples were pre-, per-and postoperatively collected. These samples were analyzed in the lab of kidney damage biomarker alanine aminopetidase (AAP), which represents a measure of kidney damage. Results: The highest value of AAP in the urine was found in the first urine sample 30 min after reperfusion. SEVO had a value of 0.268 U / Creat (N = 11) and SERE 0.100 U / Creat (N = 14). There was no significant difference in this sample demonstrated (P = 0.344). In the preoperative sampling (Sevo: 0.031 U / Creat, SERE: 0.019 U / Creat, P = 0.013) and intraoperative sample after induction (Sevo: 0.037 U / Creat, SERE0, 017 U / Creat), P = 0.004) was a significant difference found. After calculating the absolute values of this difference there was no longer a significant difference. Conclusion: The findings in this study show no significant difference between the research groups as the kidney damage is objectified by the biomarker AAP. Further research with a higher number of patients and multiple biomarkers will provide a solution to the limitations of this study.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Moeke, Drs. G.J. anesthesioloog UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:03 |
| Last Modified: | 25 Jun 2020 11:03 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2347 |
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