Bult, L. (Lotte) (2019) Rate, causes and predictors of 7-year all-cause mortality in COPD. thesis, Medicine.
Full text available on request.Abstract
English abstract Background: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality and it is predicted to become the third leading cause of death worldwide by 20301,2. In a well-characterized COPD population we aimed to investigate the rate, causes and possible predictors of all-cause mortality. Patients and methods: COPD patients of which different characteristics were previously accessed in a study on physical activity, were included and the rate, causes and possible predictors of all-cause mortality were accessed after 7 years. Results: A total of 117 COPD patients were included in the analysis (68% male; mean age: 65 years (SD ±9); median FEV1: 50 %predicted (range 14-119), lost to follow up: 0%). After 7 years, 33 patients (28%) were dead of which 13 (39%) probably due to COPD. Independent predictors of an increased risk of death were a lower fat free mass (body composition) (HR: 0.835, 95%CI (0.699-0.996); p=0.045) and exercise capacity (HR: 0.875, 95%CI (0.782-0.980); P=0.02) and higher severity of hyperinflation (HR: 1.063, 95%CI (1.007-1.122); p=0.028) and amount of sedentary behavior (1.048, 95%CI (1.001-1.097); p=0.044). Next to this, muscle function and dyspnea severity were univariately associated with mortality. Severity of COPD, comorbidities, physical activity and the BODE-index were also univariately associated with mortality, however they were not significant independent predictors. Smoking status/history, exacerbations and mental health were not associated with a higher mortality rate. Conclusion: We identified an average mortality rate of 4.0% per year of which 39.4% of the diseased patients died of COPD. Next to this, we identified an increased risk of death associated with a lower fat free mass (body composition) and exercise capacity and a higher severity of lung hyperinflation and amount of sedentary behavior at baseline.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor(s): J.E. Hartman; and Hacken, N. H. T. ten and Hospital: UMCG Groningen and Department: Pulmonology |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:03 |
| Last Modified: | 25 Jun 2020 11:03 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2342 |
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