Veen, A. van der (Arjen) (2017) Surgical management of esophageal and gastric neuroendocrine- and mixed adenoneuroendocrine carcinoma. thesis, Medicine.
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Abstract
Introduction Neuroendocrine- and mixed adenoneuroendocrine carcinomas (NEC, MANEC) of the esophagus and stomach are very rare. Optimal treatment strategies remain unknown. Based upon mostly outdated and partly Asian literature, survival is poor. This study aimed to describe survival, choices of treatment and accuracy of biopsy diagnosis. Methods Patients with MANEC or NEC of the esophagus or stomach, who underwent surgical resection between 2006-2016, were included from the nationwide network and registry of histo- and cytopathology of the Netherlands (PALGA). Kaplan Meier survival analysis and log-rank tests were used for calculating and comparing survival outcome. Results A total of 47 patients (9 esophageal MANEC, 12 esophageal NEC, 8 gastric MANEC and 18 gastric NEC),were included. Neither for esophageal nor for gastric cancer did survival significantly differ between NEC and MANEC patients (p=0.902 and p=0.237 respectively). For esophageal cancer (NEC and MANEC pooled together), the median survival was 45 months. The 1-, 3- and 5-year overall survival (OS) were 74%, 52% and 38%, respectively. For gastric cancer, the median survival was 41 months and 1-, 3- and 5-year OS were 73%, 58% and 45%, respectively. Twenty out of 24 (NEC) and 3 out of 3 (MANEC) biopsy diagnosis were concordant with diagnosis by resection . However, biopsy diagnosis of 17 adenocarcinoma and 3 other tumors, were in fact 11 MANEC and 9 NEC on resection. Biopsy of recurrence was taken in 8 patients with MANEC, showing 5 NEC component, 3 MANEC and 0 adenocarcinoma component. Conclusion NEC and MANEC of esophagus and stomach showed a relatively good survival after resection, comparable with those of adenocarcinoma and squamous cell carcinoma from literature. Curative treatment should therefore be attempted when feasible. NEC and MANEC had similar survival. Recurrence of MANEC never contained an isolated adenocarcinoma component, suggesting MANEC should be treated as NEC.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Surgical oncology, University Medical Center Groningen and Faculty supervisor: and Ginkel, dr. R.J. van (surgeon) |
| Supervisor name: | Secondary supervisor: and Hillegersberg prof. dr. R. van (surgeon) and Daily supervisor: and Seesing, M.F.J. (PhD candidate) and Surgical oncology, University Medical Center Utrecht |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:03 |
| Last Modified: | 25 Jun 2020 11:03 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2333 |
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