Heijden, H.S. van der (2016) Epidemiology of Functional Gastrointestinal Disorders among Antillean Adolescents and the Influence of Biopsychosocial Factors. thesis, Medicine.
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Abstract
BACKGROUND Functional gastrointestinal disorders are common among children and adolescents, but prevalence numbers from different parts of the world are lacking. Knowledge regarding the pathophysiological mechanisms is unclear. AIM To determine the prevalence of FGIDs in adolescents on Curacao and to assess the influence of biopsychosocial factors on the prevalence of abdominal pain-related functional gastrointestinal disorders (AP-FGIDs). METHODS We studied the epidemiology of functional gastrointestinal disorders in 782 Antillean adolescents, aged 11-18 years, of 6 different high schools who completed the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III version (QPGS-III) between May and September 2015. RESULTS Out of 946 questionnaires, 782 were included for further analysis. The mean age of the adolescents was 14.8 ± 1.8 years with 62% being female. FGIDs were present in 265 adolescents with a prevalence of 33.1%. AP-FGIDs were the biggest subgroup, with 121 adolescents suffering from (one of the) AP-FGIDs. In total, 77 patients met criteria for IBS (9.7%), 19 for AM (2.4%), 19 for FAP(S) (2.4%) and 9 for FD (1.1%). AP-FGIDs were more common in females (OR 2.33, CI 1.48 – 3.37, p<0.001). After multiple regression and correction for sex, somatic symptoms such as nausea, loss of appetite and photophobia remained significantly associated with the presence of an AP-FGID. Certain stressful events were also associated (p<0.05) with AP-FGIDs: an alcohol drinking parent, domestic violence, emotional abuse and stress as defined by the adolescent. CONCLUSIONS AP-FGIDs are common in adolescents in Curacao. Somatic symptoms and stressful related events are associated with the prevalence of AP-FGIDs.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Bodewes, drs. F.A.J.A. kinderarts |
| Supervisor name: | Dagelijks begeleider: and Zeevenhooven, J. PhD-student / and Benninga, prof. dr. M.A. kinderarts and Sint Elisabeth Hospitaal Curaçao, AMC Amsterdam and Kinder Maag-, Darm- en Leverziekten |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:03 |
| Last Modified: | 25 Jun 2020 11:03 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2332 |
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