Visscher, J. (Jacolien) (2012) Cardiovasculair functioneren en informatieverwerking bij kinderen met een aandachtstekortstoornis: de rol van genetische moderatoren. thesis, Medicine.
Full text available on request.Abstract
A main feature of children with attention-deficit/hyperactivity disorder (ADHD) is concentration problems. They often show poorer performance on information processing tasks than their healthy controls. Neurophysiological brain arousal (e.g. as measured by EEG) is essential for the quality of executive functioning (EF, such as working memory and concentration). A recent study has shown that a higher resting BRS (baroreceptor sensitivity) is related to poorer cognitive performance specifically in children with ADHD. The present study investigates if genetic polymorphisms show a moderation effect for this relation between the BRS and EF. We added an interaction term between the BRS and selected so-called ‘single nucleotide polymorphisms (SNP) to our regression analyses. This study is part of the clinical cohort of the TRacking Adolescents’ Individuel Lives Survey (TRAILS) study. The obtained data are from 181 children between 10-12 years old, ADHD was ascertained with the DISC (Diagnostic Interview Schedule for Children). We found an interaction effect for only four SNPs; from the ADRA2a, KCNMB1 and SCL6A3 (DAT1) genes. The results implicate that the presence or absence of specific alleles can have a protective effect or form a risk for poorer EF in relation to a high BRS. Because of the large amount of statistic analyses there is a possibility of chance capitalization. More research is required to confirm the current preliminary findings.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Hoekstra, dr. P.J. |
| Supervisor name: | Extern begeleider: and Dietrich, Dr. .A. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:03 |
| Last Modified: | 25 Jun 2020 11:03 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2301 |
Actions (login required)
 |
View Item |