Cate, Ivonne M. ten (2012) Native lung function improves after unilateral lung transplantation in patients with pulmonary fibrosis : Natieve longfunctie verbetert na unilaterale longtransplantatie bij pulmonaire fibrose. thesis, Medicine.
Full text available on request.Abstract
Background: Pulmonary fibrosis is a heterogenous group of diseases and usually an irreversible condition for which no effective treatment is available except for lung transplantation. Although various immunosuppressants has been attempted for the treatment of this disease, the triple immunosuppressive therapy such is given post –transplantation has never been used for this purpose. Recipients from single lung transplants provide an unique opportunity to follow the function of the native lung over time in the setting of this triple immunosuppressive treatment. To determine the effect of this treatment, we evaluated the course of the function of the native lung of our lung transplant recipients who underwent a single lung transplant for pulmonary fibrosis. Methods: In this retrospective study, we included all patients who underwent a single lung transplantation between 1990-2010 because of pulmonary fibrosis. Routinely obtained quantitative ventilation scans and Inspiratory Vital Capacity (IVC) were available from 17 patients and used to calculate the IVC of the native lung over time. Change in the decrease of IVC pre- and post transplant was analysed with Wilcoxon ranking test and individually a minimal clinical important difference (MCID) of 5% IVC was used. Results: There was a significant improvement in the course of IVC pre- and posttransplantation; the median change in ml IVC per year was -70 (-790-220) ml pre –transplantation and +25 (-210 tot 985) ml post –transplantation (p=0.007). 4 out of 17 patients showed a significant improvement of IVC. In 2 patients the lung function of the native lung stabilized within 95-105% of the pre –transplantation IVC. The median difference of the IVC pre- and one year posttransplantation was -90ml. Conclusion: The course of lung function of pulmonary fibrosis patients improves after lung transplantation. This is most likely caused by the immunosuppressive regimen.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Verschuuren, dr. E.A.M. and Universitair Medisch Centrum Groningen and Afdeling Longtransplantatie |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:03 |
| Last Modified: | 25 Jun 2020 11:03 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2267 |
Actions (login required)
 |
View Item |