Rommers, W. (Wieke) (2014) De mening van zwangere vrouwen en zorgverleners over prenatale testen voor het syndroom van Down; Een discrete choice experiment ter vergelijking van non-invasieve prenatale testen en huidige invasieve testen. thesis, Medicine.
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Abstract
Current techniques with the capability to provide information on the genetic material of a fetus are invasive (chorionic villus sampling and amniocentesis) and have a 0,3 to 0,5% risk of inducing a miscarriage. In 1997 it was discovered that fetal DNA is present in the maternal bloodstream. After many developments this discovery has led to non-invasive prenatal tests (NIPT) for Down syndrome (and trisomy 13 and 18). This test has a higher sensitivity and specificity than the combined test. However, does this really contribute to the prenatal care in the Netherlands? We’ve performed a discrete choice experiment (DCE) amongst caregivers in prenatal care and pregnant women to research which qualities of a prenatal test are deemed important and which tests are preferred. We’ve included 393 pregnant women (≥ 14 weeks pregnant) and 121 caregivers in total. The most important difference between the two groups was that caregivers value the accuracy of a test more and would prefer to have the test in an early stage of the pregnancy. Pregnant women on the other hand are prepared to wait 17 weeks longer for a test if it has no risk of inducing a miscarriage. Caregivers are prepared to accept a small risk of iatrogenic miscarriage if it would make a test more accurate. We also saw a preference in pregnant women for tests which provide more extensive information on the fetus. With the introduction of the NIPT the needs of both groups will be met; namely because the NIPT is more accurate than the combined test which reduces the need for invasive testing and it is safer than invasive tests. The NIPT can therefore be deemed a positive contribution to prenatal screening in the Netherlands.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Bilardo, Prof. Dr. C. M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:02 |
| Last Modified: | 25 Jun 2020 11:02 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2241 |
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