The relation between striatal dopaminergic activity (F-DOPA-PET), UPDRS and movement parameters derived from functional tests in patients with Parkinsonism.

Blikman, L.J.M. (2010) The relation between striatal dopaminergic activity (F-DOPA-PET), UPDRS and movement parameters derived from functional tests in patients with Parkinsonism. thesis, Human Movement Sciences.

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Abstract

Parkinsonism covers a number of progressive neurodegenerative movement disorders, including Parkinson's disease (PD). They are characterized by a triad of tremor, bradykinesia and rigidity. At the basis lies reduced activity of dopaminergic neurons in the substantia nigra causing a reduction of dopamine uptake in the striatum. This study examined the relations between the distribution of striatal dopamine uptake reduction (F-dopa ratio) as measured with F-dopa PET scans, the scores for motor functioning as measured with the motor part of the Unified PD Rating Scales (UPDRS) and kinematic parameters for (loco )motor performance. For the latter we investigated additional performance based tests, respectively the Timed up and Go (TUG) and the newly developed Cups Grasp and Turn test (CGT). In this study 8 PD patients (4 male, 4 female; aged 65.6 ± 7.8 years; UPDRS 22.6 ± 7.1) were tested 'off' anti-Parkinson medication. The TUG and CGT test were each performed under normal circumstances (single task) and with an additional task (dual task: counting while performing). Only step frequency of the TUG was significantly correlated with the motor UPDRS score. Significant correlations with the F -dopa ratio were absent. However, several kinematic parameters of both tests showed tendencies to correlate with the UPDRS as well as with the F -dopa ratio and also showed dual tasking effects. Therefore, the parameters from the TUG and CGT test have the potential to detect progression ofPD and respond to symptomatic and disease modifying treatments. The results are promising, but need to be confirmed in studies with larger samples.

Item Type:	Thesis (Thesis)
Supervisor name:	Maurits, N.M. and Kamsma, Y.P.T.
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 11:02
Last Modified:	25 Jun 2020 11:02
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/2208

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