Ginkel, M. van (Marthe) (2017) B/T ratio increases with higher severity of lymphoepithelial lesions insalivary glands of patients with primary Sjögren’s syndrome. thesis, Medicine.
Full text available on request.Abstract
Primary Sjögren’s syndrome (pSS) is one of the most common chronic systemic autoimmune diseases. The disease is characterized by dry mouth and dry eyes, although systemic manifestations in almost all organ systems and mucosal surfaces can be present. The characteristic histopathological finding in the salivary glands of pSS patients is a focal lymphocytic infiltrate, which is located around the striated ducts. Within the periductal infiltrate, lymphoepithelial lesions (LELs) can be formed. LELs are defined by infiltration of lymphocytes within the ductal epithelium with subsequent hyperplasia of basal cells. LELs can be scored in 4 stages of severity. Ranging from infiltration of lymphocytes without hyperplasia of the epithelium (stage 0) to a totally occluded lumen with hyperplasia of the whole epithelium (stage 3). This study was performed to get more insight in the formation of LELs and the role of B and T lymphocytes in this process. In 9 parotid and 12 labial gland biopsies, LELs were scored according to severity and B and T lymphocytes within LELs were counted. It was found that both B and T lymphocytes can be present within the ductal epithelium of the LELs. With increasing severity of the LELs, both the numbers of B and T cells increased. Numbers of B cells increased more than the number of T cells, causing an increase in B/T ratios with higher severity. In LELs without proliferating epithelium (stage 0), B cells were mostly absent. When the epithelium was proliferating (stage 1-3), B cells were present and mostly located in the hyperplastic areas. These results indicate a major role for B cells in the formation of LELs. There is a close interaction, or crosstalk between lymphocytes and the ductal epithelium in salivary glands of pSS patients.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider and Kroese, Prof. Dr. F.G.M. and Reumatologie en Klinische Immunologie and Tweede begeleider and Vegt, Dr. B. van der and Pathologie en Medische Biologie |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:01 |
| Last Modified: | 25 Jun 2020 11:01 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2159 |
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