Foreman, A.B. (Anne Britt) (2018) Effects of current exposure to bisphenols and parabens on attention and concentration in adolescents. thesis, Medicine.
Full text available on request.Abstract
Background: Parabens and bisphenols are environmental pollutants used in plastic food packaging and personal care products, which may act as endocrine disruptors. Pre- and postnatal exposure has negative effects on attention and concentration in school-age children. Less is known about adolescence. Bisphenol A (BPA) is partly replaced by analogues, such as bisphenol S (BPS). Whether BPS may have the same detrimental effects as BPA is unknown. Objective: To determine the effects of current exposure to parabens and bisphenols on attention and concentration in adolescents, in general and by gender. Methods: 188 children (aged 13-15 years old) and their mothers, from two birth-cohorts, were invited to participate in this follow-up study as part of the Development at Adolescence and Chemical Exposure (DACE) study. Levels of five parabens and three bisphenols were measured in morning urine after overnight fasting, using a validated liquid chromatography-tandem mass spectrometry methodology. A custom-made panel of analytes was used. We performed the Test of Everyday Attention in Children (TEA-Ch) to determine selective and sustained attention, and the parents filled in the Dutch Attention Deficit Hyperactivity Disorder questionnaire (AVL), to determine attention, hyperactivity and impulsivity. A higher raw score indicated a poorer outcome for the AVL and the selective attention TEA-Ch subtest, and a lower raw score indicated a poorer outcome for the sustained attention TEA-Ch subtest. Partial Spearman’s rho coefficients were calculated and logistic regression analyses done to test associations between compound levels and test scores, adjusted for age at examination, gender, BMI, maternal age at delivery, maternal education, maternal alcohol use and smoking during pregnancy, breastfeeding and urine creatinine levels. Associations with p<0.10 were seen as marginally significant and associations with p<0.05 as significant. Results: 101 (54%) mother-child pairs participated. Paraben levels were higher in girls than boys. Higher methylparaben levels were associated with lower attention scores (Rho = -.206; p= .055; ♀ Rho= -.406; p= .013) and a lower total AVL score. Higher ethylparaben was associated with lower attention scores (Rho = -.198; p = .066; ♀: Rho= -.425; p= .009). Higher ethylparaben was associated with a lower total AVL score (♀: Rho = -.406; p = .013), lower hyperactivity score (Rho = -.193; p= .074; ♀: Rho= -.319; p= .055) and higher scores for selective attention (♂: Rho = .289; p= .054). Higher bisphenol S levels were associated with higher total (♂: Rho = .314; p= .040) and hyperactivity score (♂: Rho = .370; p= .015). Higher propylparaben levels were associated with abnormal scores on sustained attention (OR: 1.026; 95% CI:0.996-1.058; p= .095). Higher bisphenol A was associated with lower selective attention scores (♂: Rho= -.291; p= .052). Conclusion: Higher ethylparaben and methylparaben exposure was associated with better scores on attention and less hyperactivity in 13 to 15-year-old adolescents, especially in girls. Higher ethylparaben was associated with poorer selective attention in boys and higher propylparaben was associated with poorer sustained attention in the total cohort.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Bos, A.F. and Tweede begeleider: and Berghuis, S.A. and Neonatologie/Kindergeneeskunde UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:01 |
| Last Modified: | 25 Jun 2020 11:01 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2139 |
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