Broeke, A. ten (2013) Active Care after Kidney Transplantation. thesis, Medicine.
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Abstract
Background: Cardiovascular disease is a very common problem among renal transplant recipients (RTRs) and it is the major cause of death in this patient group. Physical activity (PA) seems to be beneficial to RTRs, but they often have a low PA level. At the moment, physical training is not part of usual care after renal transplantation. In this preliminary analysis of the randomized controlled trial GRN-ACT, we aimed to investigate the effects of an exercise intervention in the first year after transplantation on the cardiometabolic profile of RTRs. Methods: Twenty-eight RTRs participating in the GRN-ACT study were included. Patients were randomly assigned to the exercise (n=19) or control (n=9) group. Patients assigned to the exercise group followed a 12-week supervised exercise program. Measurements were performed before and after the exercise intervention. We analyzed change in lipid-lipoprotein status, blood pressure, weight, waist/hip ratio, body composition, fasting plasma glucose level and prevalence of the metabolic syndrome. In addition, we investigated change in renal function, muscle strength and exercise capacity after the exercise intervention. Results: We found no significant changes in cardiometabolic profile after three months, except for an increase in body fat percentage in both the exercise and usual care group (p=0.002 and p=0.02, respectively). The exercise group had an increase in muscle strength in three different movements (p=0.002, p=0.004 and p=0.008). Renal function and exercise capacity did not change. Conclusion In this preliminary analysis we did not find significant effects of an exercise intervention on the cardiometabolic profile of RTRs. However, physical activity did improve muscle strength. Large trials are needed to establish effectiveness of physical activity in RTRs, we should therefore await the results of the GRN-ACT study.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Bakker, dr. S.J.L. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:00 |
| Last Modified: | 25 Jun 2020 11:00 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2031 |
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