Hommel, M. (Matthijs) (2016) Luminal Preservation in Rats : An Experimental Study. thesis, Medicine.
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Abstract
Intestinal transplantation is the last resort when parenteral nutrition fails in the treatment of intestinal failure. Despite improvements in surgical techniques and specialized care, survival rates have barely improved in the last decade and numbers of intestinal transplantations are decreasing. With the current standard perfusion and preservation techniques, the intestinal mucosa deteriorates fast after procurement. Slowing down the mechanisms behind ischemic damage to reduce the inevitable ischemic reperfusion injury is therefore of great importance. Luminal preservation has shown its potential as a new preservation technique, but has never been tested in combination with brain death animals, which is of relevance since only the intestines of brain death donors are accepted for donation. This study investigated the effect of luminal preservation with PEG and glutamine on the intestine of brain death Lewis rats (n=8 per group). Results were compared with luminal preservation with WMEplus. No significant improvement was found for either luminal solution. Morphology had already deteriorated after procurement. Current results need to be compared to healthy control. This study shows that a combination of brain death and warm ischemia has a devastating effect on the intestinal mucosa. Its results state the importance of an effective preservation technique to conserve intestinal grafts and consequently increase the time window of cold ischemia.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Haveman, J.W. MD and Daily supervisor: and Trentadue, G. MD and Department: Surgical Research Laboratory, Dep. of Surgery and UMCG, Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:40 |
| Last Modified: | 25 Jun 2020 10:40 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/203 |
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