Chamoun, P. (Philippe) (2012) Postoperative cognitive dysfunction in elderly cancer patients (PICNIC) : Invloed type anesthesie op het ontwikkelen van Post Operatieve Cognitieve Dysfunctie (POCD). thesis, Medicine.
Full text available on request.Abstract
Aims: This study focuses on examining factors that may influence the onset of memory and / or concentration problems after surgery in elderly patients with cancer. With the results insight is to be gained about the etiology and incidence of Post-Operative Cognitive Dysfunction (POCD) in these patients. This research focuses on the influence of the type of anesthesia and the development of POCD. It is attempted to determine possible risk factors. Based on this knowledge, it will be tried to optimizing the care for the elderly patients with cancer and to ensuring independence by preventing cognitive impairment as much as possible. Background: Cancer is common in the elderly. The majority of patients with a solid tumor is being treated by surgery, whether or not in combination with (neo) adjuvant radiation therapy, chemotherapy or hormonal treatment. POCD is common after surgery in the elderly. The knowledge about the incidence, impact on quality of life and the etiology of POCD in elderly patients is limited. Moreover, there is no uniform definition (standard) of POCD in literature. Methods: In this observational prospective pilot study with three month follow-up 93 patients older than 65 years undergoing surgery for a malignant tumor were included. Using the neuropsychological tests (RFFT, TMT-A and TMT-B), the incidence of POCD is identified. There are 3 test points, namely preoperative, postoperative and 3 month later. Also data were collected on possible risk factors. Results: The incidence of early and late POCD was 12.9% and 10.3%. Furthermore, the type of anesthesia did not significantly affect the development of both early and late POCD. A positive relationship has been demonstrated though. Age is the only predictor of developing early POCD, taking into account the other variables (Gender, GFI, Charlson comorbidity score and type of surgery). Conclusions: The study confirms that the development of POCD is multifactorial. Therefore, further research into the etiology desired. Of the investigated potential risk factors for POCD to develop, only age has a significant influence on the development of early POCD. It is desirable to better describe the definition and diagnosis and to use objective digital testing possibilities and testingtools
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and Leeuwen, Dr. B.L. van and UMCG oncologische chirurgie en geriatrie |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:00 |
| Last Modified: | 25 Jun 2020 11:00 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2008 |
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