Roeleveld, M. (Mirte) (2017) Level and time course of immune factors in the acute inflammation phase of respiratory syncytial infection and the later link with pulmonary morbidity. thesis, Medicine.
Full text available on request.Abstract
A lot of studies report associations between local and systemic cytokine concentrations and a severe respiratory syncytial virus (RSV) infection. In addition, a lot of studies find an association between early life viral infections with pulmonary morbidity. Here, we determined, to our knowledge for the first time, the relation between cytokine concentrations on pulmonary function. In addition, we assessed inflammatory effect of high frequency oscillation (HFO) is determined by comparing cytokine concentrations in children that received HFO versus conventional ventilation treatments. Tracheal aspirates (TA) and blood samples (serum) where taken at day 1, 3 and 5 in children with a severe RSV infection during their stay at the paediatric intensive care unit. Six months after recovery, 27 children underwent lung function test with a baby-box plethysmograph. The correlation between levels- and time courses of cytokines and damage-associated molecular patterns (DAMPS) in tracheal aspirate and serum samples coupled to lung function test based on Z-scores of the functional residual capacity (FRC) and maximal volume expired over the first second (VmaxFRC). In addition, cytokine concentrations were compared between children that received HFO and conventional ventilation. We find that lower pulmonary cytokine concentrations are associated with a high FRC, whereby high systemic cytokine concentrations are associated with low VmaxFRC. The FRC is independent of prematurity, whilst VmaxFRC is dependent of prematurity. There are no differences between cytokine concentrations between premature and à term children. HFO ventilation is associated with a more protective inflammation response compared to conventional ventilation.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervision by and Kneyber, M.C.J and Department of Paediatrics, division of Paediatric Critical C and Beatrix Children’s Hospital, University Medical Center Groni |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:40 |
| Last Modified: | 25 Jun 2020 10:40 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/200 |
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