Boer, S.A. (Stefanie) de (2012) De toegevoegde waarde van autofluorescentie – naast de UKPDS-risicofunctie – voor de bepaling van het risico op hart- en vaatziekten bij type 2 diabetes mellitus patiënten. thesis, Medicine.
Full text available on request.Abstract
Background: The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus (T2DM). The AGE reader was recently introduced as an alternative tool for risk assessment in diabetes mellitus. The AGE reader measures, in a non-invasive way, tissue accumulation of Advanced Glycation Endproducts (AGEs) by means of fluorescence techniques (skin autofluorescence (SAF)). AGEs play a key role in the pathogenesis of complications of diabetes mellitus and atherosclerosis. This study is set up to investigate if there is an added value of SAF, in addition to the UKPDS risk engine, in T2DM patients managed in secondary care, without concurrent cardiovascular (CV) complications. Method: Cross-sectional patient study in 180 T2DM patients, without concurrent CV complications, managed in secondary care. SAF was measured and the UKPDS risk score was calculated during a regular appointment in the period from April 2012 until July 2012. Patients were classified as low risk when their 10 year UKPDS risk score for fatal cardiovascular events was < 10%, and as high risk when this risk was > 10%. SAF was classified by the median (i.e. low risk < median, high risk > median). Results: The addition of SAF to the UKPDS risk score leads to a discordance between SAF and the UKPDS risk score in 52% (N=93) of patients (N=180). The addition of SAF to the UKPDS risk score leads to reclassification fn 56% (N=64) of low or medium risk patients to high risk patients. There are no risk factors which declare the discordance between the UKPDS risk engine and SAF. Conclusion: There is an added value of SAF for cardiovascular risk assessment, in addition to the UKPDS risk engine, in T2DM patients managed in secondary care, without concurrent cardiovascular complications.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Smit drs. A.J. (facultair begeleider), Universitair Medisch |
| Supervisor name: | Hoogenberg, drs. K. Martini ziekenhuis and Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:59 |
| Last Modified: | 25 Jun 2020 10:59 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1990 |
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