Effect of Irradiation on stem cell based delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) in gliomas

Boer, N.L. de (Nadine) (2013) Effect of Irradiation on stem cell based delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) in gliomas. thesis, Medicine.

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Abstract

Glioblastoma multiforme (GBM) is the most common and aggressive form of brain tumor and accounts for more than half of these cases. Despite clinical advances over the last few years, the median survival for patients with this malignancy has not been significantly improved. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) that has been proven to posses cancer cell specific killing potential, has drawn considerable attention for anti-tumor therapy. However, studies have shown that a significant subpopulation of the heterogeneous GBMs are TRAIL resistant. In this study, we aim to explore the effect of irradiation on sensitizing TRAIL resistant GBM cells to stem cell delivered TRAIL therapy and to mechanistically evaluate the pathways contributing to modulation of TRAIL sensitivity. Our studies demonstrate that irradiation specifically increases the surface expression levels of death receptors (DR) 4/5 on GBM cells and sensitizes GBM cells to TRAIL mediated apoptosis. We expect that these studies will have implications in translating TRAIL based therapies into clinics for treating GBMs.

Item Type:	Thesis (Thesis)
Supervisor name:	Kruyt, Prof. Dr. Frank and University Medical Center Groningen and The Department of Medical Oncology and University of Groningen
Supervisor name:	Shah, Dr. Khalid and Massachusetts General Hospital and Department of Radiology/Neurology and Molecular Neurotherapy and Imaging Lab and Harvard Medical School
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:59
Last Modified:	25 Jun 2020 10:59
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1986

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