Zelst, C.M. van (Cathelijne-Marianne) (2018) Relation between serum lipid levels and inflammatory markers of asthmatic patients and healthy controls with normal and high BMI :Retrospective study. thesis, Medicine.
Full text available on request.Abstract
Background: Asthma is a chronic heterogeneous disease characterized by bronchial hyperresponsiveness and airway inflammation. Obesity asthma is a relatively new phenotype of asthma in adults, whereby adults with an increased body mass index (BMI) have a relative increased risk of developing asthma. Overweight has a negative influence on lung function, and obese adults exhibit more severe asthma symptoms. The pathophysiological link between obesity and asthma is still unclear. It is possible that, in obese patients, systemic inflammation is playing a role in initiating asthma symptoms. Study objective: To explore the relation between lipid level and inflammatory markers (eosinophils and neutrophils) in blood of asthmatic patients and controls with different BMI-ranges. Methods: In this retrospective study, the baseline data of three studies is used. Asthma patients (n=93) and healthy controls (n=45) were divided into three BMI-ranges (<30kg/m2, 30-40kg/m2 and >40kg/m2). Data of venous blood was collected to analyze the systemic inflammation and lipid profile. Also, to determine the presence of a metabolic syndrome (abdominal circumference, blood pressure, glucose, triglyceride level and HDL-ratio in blood) was collected. Results: Serum triglyceride was significantly increased in asthma patients with a BMI >40kg/m2 (p=0,006), compared to healthy controls in this BMI-range. Also, neutrophils are significantly increased in patients with a high BMI, corrected for asthma, sex and metabolic syndrome. Eosinophils are significantly increased in asthma patients, corrected for BMI, sex and metabolic syndrome. Conclusion: Patients with asthma and a high BMI (>40kg/m2) have significantly elevated serum triglyceride levels, compared to healthy controls in this BMI-range. LDL-cholesterol and total cholesterol were not significantly elevated in asthma patients with an increased BMI. It is possible, that serum triglyceride is an inflammatory marker in asthma patients. The role of triglycerides in inflammation needs to be clarified in the future.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Kuipers, drs. A.F. and Pulmonologist Isala Klinieken Zwolle |
| Supervisor name: | Day-to-day supervisor: and Boer, drs. G.M. de PhD-candidate Franciscus Gasthuis Rotterd and Second supervisor: and Braunstahl, dr. G.J. and Pulmonologist Franciscus Gasthuis Rotterdam and Department: Pulmonology, Franciscus Gasthuis Rotterdam |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:40 |
| Last Modified: | 25 Jun 2020 10:40 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/198 |
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