Balvers, K. (Kirsten) (2013) MRI als voorspellende diagnostiek voor angiogenese bij vasculaire malformaties. thesis, Medicine.
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Abstract
Background: Angiogenesis in vascular malformations of skin and soft tissue are observed in recent studies. Most of these patients with angiogenesis become symptomatic and be treated surgically. The MR imaging could be used to analyse demographic data, topographic location and the flow characteristics of the malformation before treatment. The MR imaging is a technique designed for fast vascular imaging, is non-invasive and very specified. Aim: To systematically investigate whether MR imaging is allowed to diagnose angiogenesis in symptomatic vascular malformations before surgery. Methods: Retrospective 37 resection specimens of symptomatic vascular malformations were screened histopatologically for the presence and extent of angiogenesis. MR imagine before sugery screened the vascular malformations for the presence of solid masses en flow. Both groups were compared with each other. Results: Histopathologically we found in 21 patients areas of angiogenesis; 5% single cluster of immature capillaries, 43% multiple clusters and 53% extensive diffuse and solid proliferation. In 16 patients we found no areas of angiogenesis. Of the patients with angiogenesis 57% showed (partial) immature proliferations and 43% mature proliferations. MR-imaging found 10 patients with solid masses. 80% Of these solid masses correlates with angiogenesis diagnosed histopathologically. MRI is allowed to predict immature proliferation significantly (P=0.049). 30% Of the patients showed a progression of angiogenesis after surgery. Conclusion: MR imaging with solid masses in vascular malformations is allowed to diagnose 80% of angiogenesis in vascular malformation. In most of the cases, in which MR imaging founded a solid masses, the vascular malformations were diagnosed with immature proliferations. MR imaging without solid masses can not predict the presence of angiogenesis. MR imaging is also allowed to diagnose the flow in vascular malformations. Resection of vascular malformations showed a progression of angiogenesis in 30% of all patients.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Dungen, Dr. J.J.A.M. van den vaatchirurg |
| Supervisor name: | Horst, Prof. dr. C.M.A.M. van der plastisch chirurg AMC (beg |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:59 |
| Last Modified: | 25 Jun 2020 10:59 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1941 |
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