Woudhuizen, S.M. (2013) Effect van hoogfrequente repetitieve transcraniële magnetische stimulatie op negatieve symptomen en cognitief functioneren bij patiënten met schizofrenie. thesis, Medicine.
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Abstract
Introduction: Schizophrenia is a chronic, severe and disabling mental disorder which manifests itself between de ages of 16 and 30. Treatment of schizophrenia primarily focuses on positive symptoms such as delusions and hallucinations with antipsychotic drugs. Negative symptoms may prove to be even more difficult to treat. Negative symptoms are described as loss of initiative (apathy), flat affect, inability to experience pleasure (anhedonie), loss of motivation (avolition) and poverty of speech (alogie). To this day there are no effective treatment-options available. Studies suggest the dorsolateral prefrontal cortex (DLPFC) is involved in the pathophysiology of negative and cognitive symptoms, mainly due to a decreased cortical activation (hypofrontality). Stimulation of the DLPFC with repetitive Transcranial Magnetic Stimulation (rTMS) has shown promising results on negative and cognitive symptoms in previous studies. Methods: This randomised double blind controlled trial investigated the effects of bilateral rTMS on negative and cognitive symptoms in patients with schizophrenia. 32 subjects were stimulated for 3 weeks at a frequency of 10Hz. The effects were measured using the Scale for the Assessment of Negative Symptoms (SANS), Positive and Negative Syndrome Scale (PANSS) and a variety of cognitive tests at baseline, 4 weeks and 3 months. Results: We found no significant improvement of rTMS on negative and cognitive symptoms. There was a significant time effect on the MADRS and psychological subscale of the Quality of Live Scale. Also some cognitive tests showed a significant improvement over time, which was not caused by the rTMS. Conclusion: We failed to show the superiority of bilateral active rTMS over sham stimulation on negative and cognitive symptoms in patients with schizophrenia.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Bais MSc, mw. drs. L. and Knegtering, hr. dr. H. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:59 |
| Last Modified: | 25 Jun 2020 10:59 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1912 |
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