Scholten, L. (Laura) (2018) Long term recurrence rates of frozen section analysis in basal cell carcinomas of the face. thesis, Medicine.
Full text available on request.Abstract
ENGLISH SUMMARY Introduction: Basal cell carcinomas (BCCs) are slow growing tumors whose treatment often consists of excision. 5-year recurrence rates are low, but little is known about the long-term recurrence rates. Aim: The aim of this study is to identify 5, 10 and 15-year recurrence rates in BCCs treated with whole specimen intraoperative frozen section analysis (WIFSA) and to recognize characteristics associated with higher recurrence rates. Method: A single-center retrospective cohort of all patients with a BCC in the face receiving surgical excision and the WIFSA technique from January 1992 until December 2007 was evaluated. Recurrence rates were examined for all BCCs and rates were compared between primary (pBCC) and recurrent BCCs (rBCC), histological subtypes and between anatomical locations. An assessment of the accuracy of WIFSA was also undertaken by comparing the results with the Formalin-Fixed Paraffin-Embedded section analysis (FFPE) results. Results: A total of 1140 patients with 1265 BCCs underwent WIFSA, and had a mean follow up of 10.1 years (range 0.0 – 25.3). We found an overall agreement of 99.0% between WIFSA and FFPE. The recurrence rates for pBCCs were 3.3% at 5 years, 5.1% at 10-years and 7.3% at 15 years. rBCCs, BCCs with a growth pattern other than nodular and BCCs located on the forehead and temples were associated with higher recurrence rates. Conclusion: The recurrence rates seen in this study imply that the standard clinical follow-up of five years may be insufficient.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and Mouës – Vink, Dr. C. plastic surgeon and Afdeling Plastische Chirurgie MCL, Leeuwarden |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:40 |
| Last Modified: | 25 Jun 2020 10:40 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/191 |
Actions (login required)
 |
View Item |