Luiting, F. (2013) Haarafwijkingen bij patienten met ernstige hypodontie ( oligodontie)):ontwikkelen van indicatoren. thesis, Dentistry.
![[img]](https://umcg.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
Luiting.pdf Restricted to Registered users only Download (29MB) |
Abstract
Introduction and research goal: The diagnosis non-syndromic severe hypodontia/oligodontia is a clinical diagnosis. The clinical geneticist observes no additional physical abnormalities when conducting a clinical examination. Consequently the diagnosis 'ectodermal dysplasia syndrome' cannot be made. Health professionals working with non-syndromic severe hypodontia/oligodontia patients believe that hairs of non- syndromic oligodontia patients appear abnormal, even though this is not confirmed by a clinical geneticist. The goal of this research is to develop parameters and measures to study hair shaft abnormalities to be applied in ectodermal dysplasia patients with oligodontia (group 1), patients with non-syndromic severe hypodontia/oligodontia (group 2) and unaffected control patients (group 3). These measures will be tested in a pilot study. Material and methods The research data (group 1, n=7 and group 2, n=4) that is used in this research is derived from patients of the 'Centre for Special Dental Care of the UMC Groningen' and the social network of the researcher (group 3, n=6). Hairs (15-30 samples) were cut from different spots on the heads of the participants by using a scissor. They were embedded in 'mounting medium' and for every participant two coupes were made. These coupes were examined for hair shaft abnormalities by using (polarized) light microscopy. Images were made from a couple of hair shaft abnormalities. The collection and analysis of the hairs is done unblinded. The results of the different groups were compared by using the chi-square test. The data from within the group is listed,based on the attendance rate of hair shaft abnormalities. Results In every group the following hair shaft abnormalities were found; trichorrhexis nodosa (64.7%), trichoptilosis (29.4%) and 'other' (64.7%). The remaining hair shaft abnormalities were absent in all three groups. Trichorrhexis was especially found in group 1. Trichorrhexis nodosa was in particular seen at hair shafts with a small diameter. Trichoptilosis was found in every group with the highest attendance rate in group 2. All hair shafts that contain trichoptilosis were found in female participants. 'Other' hair shaft abnormalities were also found in every group with the highest attendance rate in group 2. The abnormality 'barcode phenomenon' and hair shafts with a small diameter were only found in group 1. A broken cuticula was only found in group 2. The remaining 'other' abnormalities were found in more than one group. None of the findings were statistically significantly different. Discussion and conclusion It is possible to identify hair shaft abnormalities by using (polarized) light microscopy. However theresults of this research show that it can be assumed that differences between the three groups can not be identified when using (polarized) light microscopy. Most of the results are not specific and sensitive enough for the identification of the required differences. Based on these results it is not possible to answer the question, if severe hypodontia/oligodontia could be a subclinical ectodermal dysplasia syndrome. Further research must show if the 'bar code phenomenon', small diameter hairshafts and broken cuticula are pathognomonic findings or that the current findings are pure coincidence. Previous research was not able to identify any pathognomonic finding. In addition the strengths and weaknesses of this research are deliberated and suggestions for further research are made.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Cune Prof. Dr. M.S.en and Visser, Dr. A. and Bijzondere Tandheelkunde and Orale Functieleer |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:40 |
| Last Modified: | 25 Jun 2020 10:40 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/188 |
Actions (login required)
 |
View Item |